Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5656222 | 0.71 | MAPT (0.53) | GAAMAPTADORA1ADORA2AADORA2B | |
| SCHEMBL14588482 | 0.63 | MAPT (0.59) | GAAMAPTADORA1ADORA2AADORA2B | |
| SCHEMBL2761139 | 0.61 | MAOB (0.44) | GAAADORA1ADORA2AADORA2BPDE4B | |
| SCHEMBL11704650 | 0.60 | MAPT (1.00) | GAAMAPTADORA1KMT2AMEN1 | |
| SCHEMBL21805040 | 0.59 | KCNA5 (0.43) | ADORA1ADORA2AADORA2BPDE4BPDE4D | |
| SCHEMBL23621132 | 0.59 | TAAR1 (0.59) | BACE1 | |
| SCHEMBL11728696 | 0.57 | PTGES (0.47) | MAPTADORA1ADORA2AADORA2BKMT2A | |
| SCHEMBL5593362 | 0.57 | AGTR1 (0.74) | GAAMAPTADORA1ADORA2AKMT2A | |
| SCHEMBL5658316 | 0.57 | MAPT (0.41) | GAAMAPTADORA1ADORA2AADORA2B | |
| SCHEMBL10810284 | 0.56 | ADORA1 (0.48) | GAAMAPTADORA1ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322636-A1 | FARNESYL TRANSFERASE INHIBITING 6- (SUBSTITUTED PHENYL)METHYL]-QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024683-A1 | FARNESYL TRANSFERASE INHIBITING 6-[(SUBSTITUTED PHENYL)METHYL]-QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-28 | — | — | WO | disclosed |