Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138046 | 0.94 | KDM4E (0.38) | SMN1; SMN2KDM4EALDH1A1TSHRTP53 | |
| SCHEMBL7144053 | 0.82 | GAA (0.40) | ALDH1A1TSHRTP53MAPTEPHX2 | |
| SCHEMBL3479817 | 0.81 | MAPK9 (0.53) | SMN1; SMN2KDM4EALDH1A1TSHRTP53 | |
| SCHEMBL3479811 | 0.81 | MAPK9 (0.51) | SMN1; SMN2KDM4EALDH1A1TSHRTP53 | |
| SCHEMBL7145126 | 0.80 | GAA (0.38) | ALDH1A1TSHRTP53MAPTEPHX2 | |
| SCHEMBL7139566 | 0.79 | KDM4E (0.42) | SMN1; SMN2KDM4EALDH1A1MAPK9MAPK10 | |
| SCHEMBL7142563 | 0.79 | TP53 (0.44) | SMN1; SMN2KDM4EALDH1A1TP53MAPT | |
| SCHEMBL3479765 | 0.79 | MAPK9 (0.51) | SMN1; SMN2KDM4EALDH1A1TSHRMAPK9 | |
| SCHEMBL7139807 | 0.76 | DRD2 (0.38) | SMN1; SMN2KDM4EALDH1A1TP53MAPK9 | |
| SCHEMBL7146530 | 0.76 | KDM4E (0.45) | SMN1; SMN2KDM4EALDH1A1TP53MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322642-A2 | sHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES BEARING BOTH LIPOPHILIC AND IONISABLE MOIETIES AS INHIBITORS OF PROTEIN JUNKINASES | Applied Research Systems ARS Holding N.V. (AN) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002026733-A2 | sHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES BEARING BOTH LIPOPHILIC AND IONISABLE MOIETIES AS INHIBITORS OF PROTEIN JUNKINASES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2002-04-04 | — | — | WO | disclosed |