Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145126 | 0.97 | GAA (0.38) | GAAMAPTCHRM1TP53TSHR | |
| SCHEMBL7138079 | 0.86 | ALDH1A1 (0.41) | GAAMAPTCHRM1TSHRCYP2C9 | |
| SCHEMBL7145105 | 0.85 | CHRM1 (0.44) | GAAMAPTCHRM1TSHRCYP2C9 | |
| SCHEMBL7148318 | 0.85 | CHRM1 (0.43) | GAAMAPTCHRM1TSHRCYP2C9 | |
| SCHEMBL3480005 | 0.84 | KMT2A (0.51) | GAAMAPTCHRM1HPGDPOLB | |
| SCHEMBL7148150 | 0.84 | CHRM1 (0.46) | GAACHRM1TSHRCYP2C9CYP2C19 | |
| SCHEMBL7138046 | 0.82 | KDM4E (0.38) | MAPTTP53TSHRALDH1A1 | |
| SCHEMBL7147019 | 0.82 | SMN1; SMN2 (0.39) | MAPTTP53TSHRALDH1A1EPHX2 | |
| SCHEMBL3479746 | 0.82 | KMT2A (0.48) | GAAMAPTCHRM1HPGDPOLB | |
| SCHEMBL3480450 | 0.82 | KMT2A (0.48) | GAAMAPTCHRM1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322642-A2 | sHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES BEARING BOTH LIPOPHILIC AND IONISABLE MOIETIES AS INHIBITORS OF PROTEIN JUNKINASES | Applied Research Systems ARS Holding N.V. (AN) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002026733-A2 | sHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES BEARING BOTH LIPOPHILIC AND IONISABLE MOIETIES AS INHIBITORS OF PROTEIN JUNKINASES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2002-04-04 | — | — | WO | disclosed |