Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7157785 | 0.83 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL7150740 | 0.82 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL7150794 | 0.81 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL6639527 | 0.80 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL7185405 | 0.80 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2KMT2AHPGD | |
| SCHEMBL7156690 | 0.75 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2KMT2AHPGD | |
| SCHEMBL5165501 | 0.72 | F10 (0.37) | — | |
| SCHEMBL5164647 | 0.72 | F10 (0.40) | — | |
| SCHEMBL7153521 | 0.72 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL7153782 | 0.71 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351938-A1 | PHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-10-15 | — | — | EP | claimed |
| WO-2002057236-A1 | PHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-07-25 | — | — | WO | claimed |