Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 2/20 | 0.31 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143075 | 0.91 | MAPT (0.35) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7143905 | 0.89 | MAPT (0.34) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7143903 | 0.89 | MAPT (0.34) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7140157 | 0.87 | MAPT (0.37) | MAPTALDH1A1MAPK1CSF1RGPR174 | |
| SCHEMBL7144424 | 0.86 | CHRM3 (0.36) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7143475 | 0.84 | KMT2A (0.35) | MAPTALDH1A1CYP1A2CYP2C9POLB | |
| SCHEMBL7139736 | 0.83 | MAPT (0.40) | MAPTALDH1A1KMT2AMAPK1CSF1R | |
| SCHEMBL7140551 | 0.81 | HCAR3 (0.36) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7139645 | 0.81 | MAPT (0.43) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7146607 | 0.80 | MAPT (0.44) | MAPTALDH1A1POLBKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-B1 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6407094-B1 | 4-5-DIDEHYDRO-1,5-BENZODIAZEPIN-2-ONE DERIVATIVES; PSYCHOLOGICAL, NERVOUS SYSTEM, AND BRAIN DISORDERS; COGNITION ACTIVATORS; ALZHEIMER*S DISEASE, SCHIZOPHRENIA | HOFFMANN-LA ROCHE INC. | 2002-06-18 | — | — | US | disclosed |