Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140551 | 0.85 | HCAR3 (0.36) | KMT2AMEN1CREBBPHCAR3ALDH1A1 | |
| SCHEMBL7147347 | 0.84 | MAPT (0.36) | KMT2AMEN1HCAR3ALDH1A1MAPT | |
| SCHEMBL7145353 | 0.84 | HCAR3 (0.33) | KMT2AMEN1CREBBPHCAR3ALDH1A1 | |
| SCHEMBL7139782 | 0.83 | MEN1 (0.36) | KMT2AMEN1CREBBPHCAR3ALDH1A1 | |
| SCHEMBL7147448 | 0.82 | NPC1 (0.39) | KMT2AMEN1ALDH1A1MAPTNPC1 | |
| SCHEMBL7141800 | 0.82 | NPC1 (0.41) | KMT2AHCAR3ALDH1A1MAPTNPC1 | |
| SCHEMBL7141773 | 0.80 | ALDH1A1 (0.42) | KMT2AMEN1ALDH1A1MAPTNPC1 | |
| SCHEMBL7143075 | 0.78 | MAPT (0.35) | KMT2AMEN1HCAR3ALDH1A1MAPT | |
| SCHEMBL7698485 | 0.77 | MEN1 (0.40) | KMT2AMEN1ALDH1A1MAPTNPC1 | |
| SCHEMBL7144299 | 0.77 | TDP1 (0.40) | ALDH1A1NPC1RAB9ACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-B1 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6407094-B1 | 4-5-DIDEHYDRO-1,5-BENZODIAZEPIN-2-ONE DERIVATIVES; PSYCHOLOGICAL, NERVOUS SYSTEM, AND BRAIN DISORDERS; COGNITION ACTIVATORS; ALZHEIMER*S DISEASE, SCHIZOPHRENIA | HOFFMANN-LA ROCHE INC. | 2002-06-18 | — | — | US | disclosed |