Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 4/20 | 0.45 |
| ▸ | CDC25B | P30305 | 2/20 | 0.45 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.36 |
| ▸ | PPM1D | O15297 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.31 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7147375 | 1.00 | CDC25A (0.45) | CDC25ACDC25BGPBAR1PPM1DJAK2 | |
| SCHEMBL7147372 | 1.00 | CDC25A (0.45) | CDC25ACDC25BGPBAR1PPM1DJAK2 | |
| SCHEMBL7145023 | 0.94 | CDC25A (0.40) | CDC25ACDC25BGPBAR1PPM1D | |
| SCHEMBL7145028 | 0.94 | CDC25A (0.40) | CDC25ACDC25BGPBAR1PPM1D | |
| SCHEMBL8674922 | 0.85 | CDC25A (0.40) | CDC25ACDC25BGPBAR1PPM1D | |
| SCHEMBL14107826 | 0.85 | CDC25A (0.40) | CDC25ACDC25BGPBAR1PPM1D | |
| SCHEMBL8209307 | 0.85 | CDC25A (0.40) | CDC25ACDC25BGPBAR1PPM1D | |
| SCHEMBL3175294 | 0.85 | CDC25A (0.45) | CDC25ACDC25BGPBAR1PPM1DAKR1B10 | |
| SCHEMBL9070734 | 0.85 | CDC25A (0.45) | CDC25ACDC25BGPBAR1AKR1B10AKR1B1 | |
| SCHEMBL14107823 | 0.85 | CDC25A (0.47) | CDC25ACDC25BGPBAR1PPM1DAKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998455-B1 | DIHOMO-SECO-CHOLESTANES WITH TWO UNSATURATED BONDS IN THE SIDE CHAIN | HOFFMANN LA ROCHE (CH) | 2003-10-01 | — | — | EP | disclosed |
| US-5994569-A | USEFUL IN THE TREATMENT OR PREVENTION OF VITAMIN D DEPENDENT DISORDERS AND OF IL-12-DEPENDENT AUTOIMMUNE DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1999-11-30 | — | — | US | disclosed |