Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Triaziquone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triaziquone SCHEMBL2236656 | 0.85 | ALDH1A1 (0.43) | ALDH1A1KDM4ESLC13A5LMNAMAPT | |
| Triaziquone SCHEMBL14237202 | 0.85 | TP53 (0.35) | ALDH1A1MAPT | |
| Triaziquone SCHEMBL759304 | 0.82 | — | — | |
| Citric Acid SCHEMBL985329 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KDM4ESLC13A5LMNAMAPT | |
| Citric Acid SCHEMBL986854 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KDM4ESLC13A5LMNAMAPT | |
| Citric Acid SCHEMBL986838 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KDM4ESLC13A5LMNAMAPT | |
| Triaziquone SCHEMBL6236164 | 0.80 | ALDH1A1 (0.36) | ALDH1A1KDM4ESLC13A5LMNAMAPT | |
| Edetic Acid SCHEMBL23361308 | 0.77 | ALDH1A1 (0.35) | ALDH1A1KDM4ESLC13A5LMNAMAPT | |
| Triaziquone SCHEMBL5307413 | 0.77 | — | — | |
| Triaziquone SCHEMBL22346328 | 0.72 | DNMT1 (0.39) | LMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362083-A1 | INK-JET INK AND RECORDING MATERIAL | Ciba SC Holding AG (CH) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002055618-A1 | INK-JET INK AND RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2002-07-18 | — | — | WO | disclosed |