Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR2 | O43603 | 4/20 | 0.47 |
| ▸ | GALR1 | P47211 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDE9A | O76083 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5042961 | 0.92 | HTR6 (0.45) | GALR2GALR1MEN1KMT2APDE9A | |
| SCHEMBL5033699 | 0.90 | NPC1 (0.46) | GALR2GALR1MAPTMEN1KMT2A | |
| SCHEMBL5037857 | 0.89 | ENPP3 (0.40) | MEN1KMT2AHTR6CCR6 | |
| SCHEMBL5033414 | 0.89 | MAPT (0.41) | MAPTMEN1KMT2AHTR6TP53 | |
| SCHEMBL5033747 | 0.86 | ENPP3 (0.39) | GALR2GALR1HTR6CCR6IDH2 | |
| SCHEMBL5033423 | 0.86 | ENPP3 (0.40) | MAPTMEN1KMT2AHTR6 | |
| SCHEMBL5033442 | 0.84 | NPC1 (0.38) | MAPTHTR6NPC1 | |
| SCHEMBL5041016 | 0.84 | MAPT (0.46) | MAPTTP53POLBSMN1; SMN2NPC1 | |
| SCHEMBL5043065 | 0.83 | NPC1 (0.44) | MAPTMEN1KMT2AHTR6POLB | |
| SCHEMBL5042842 | 0.81 | MAPT (0.42) | MAPTMEN1KMT2ATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1298125-A1 | Substituted benzimidazole compounds and their use for the treatment of cancer | Aventis Pharma S.A. (FR) | 2003-04-02 | — | — | EP | disclosed |