Benzene

Benzene

SCHEMBL7148507

Cc1ccc(Nc2ccc(C)c(C)c2)cc1C.c1ccccc1

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.50
MAPT P10636 5/20 0.50
RAB9A P51151 5/20 0.50
MEN1 O00255 5/20 0.50
NPC1 O15118 4/20 0.50
HPGD P15428 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
LMNA P02545 2/20 0.50
ALDH1A1 P00352 2/20 0.50
ALOX15 P16050 1/20 0.50
HSD17B10 Q99714 1/20 0.50
L3MBTL1 Q9Y468 2/20 0.49
TAAR1 Q96RJ0 1/20 0.49
TP53 P04637 1/20 0.48
POLB P06746 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
CYP1A2 P05177 1/20 0.47
JAK2 O60674 1/20 0.47
KDM4E B2RXH2 1/20 0.47
GAA P10253 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30508518 0.95 ALDH1A1 (0.53) KMT2AMAPTRAB9AMEN1NPC1
SCHEMBL1155655 0.95 ALDH1A1 (0.53) KMT2AMAPTRAB9AMEN1NPC1
SCHEMBL31549984 0.95 ALDH1A1 (0.53) KMT2AMAPTRAB9AMEN1NPC1
SCHEMBL4826082 0.93 HPGD (0.60) KMT2AMAPTRAB9AMEN1NPC1
SCHEMBL30542248 0.93 HPGD (0.60) KMT2AMAPTRAB9AMEN1NPC1
SCHEMBL1921405 0.92 GAA (0.52) KMT2AMAPTMEN1HPGDSMN1; SMN2
Biphenyl SCHEMBL5422713 0.91 MAPT (0.49) KMT2AMAPTRAB9AMEN1NPC1
SCHEMBL9429230 0.90 MAPT (0.54) KMT2AMAPTRAB9AMEN1NPC1
SCHEMBL20850476 0.87 ALDH1A1 (0.48) KMT2AMAPTMEN1HPGDSMN1; SMN2
SCHEMBL5419302 0.87 NPSR1 (0.48) KMT2AMAPTRAB9AMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0771805-B1 Silicon containing charge transport compounds and curable compositions thereof DOW CORNING ASIA LTD (JP) 2003-05-02 EP disclosed
EP-0771809-B1 Method of manufacturing a polysiloxane charge transporting material DOW CORNING ASIA LTD (JP) 2003-04-02 EP disclosed
EP-0875791-B1 An electrophotographic photosensitive member, a process-cartridge inclusive thereof, and an image forming apparatus CANON KK (JP) 2002-07-24 EP disclosed
US-6376695-B1 ORGANOSILICON COMPOUND CONTAINING AMINE GROUP DOW CORNING ASIA LTD. (JP) 2002-04-23 US disclosed
US-6296978-B1 LIGHT SENSITIVE ELEMENTS FOR IMAGES CANON KABUSHIKI KAISHA (JP) 2001-10-02 US disclosed
EP-0772091-B1 An electrophotographic photosensitive member, a process-cartridge inclusive thereof, and an image forming apparatus CANON KK (JP) 2001-02-28 EP disclosed
US-5888690-A Electrophotographic photosensitive member, a process-cartridge inclusive thereof, and an image forming apparatus CANON KABUSHIKI KAISHA (JP) 1999-03-30 US disclosed
US-5879847-A Electrophotographic photosensitive member, a process-cartridge inclusive thereof and an image forming apparatus CANON KABUSHIKI KAISHA (JP) 1999-03-09 US disclosed
US-5840816-A Method of manufacturing a polysiloxane charge transporting material DOW CORNING TORAY SILICONE CO., LTD. (JP) 1998-11-24 US disclosed
EP-0875791-A2 An electrophotographic photosensitive member, a process-cartridge inclusive thereof, and an image forming apparatus CANON KABUSHIKI KAISHA (JP) 1998-11-04 EP disclosed
US-5688961-A Method of manufacturing a silicon-type charge transporting material DOW CORNING ASIA, LTD. (JP) 1997-11-18 US disclosed
EP-0772091-A1 An electrophotographic photosensitive member, a process-cartridge inclusive thereof, and an image forming apparatus CANON KABUSHIKI KAISHA (JP) 1997-05-07 EP disclosed
EP-0771805-A1 Silicon containing charge transport compounds and curable compositions thereof Dow Corning Asia, Ltd. (JP) 1997-05-07 EP disclosed
EP-0771809-A1 Method of manufacturing a polysiloxane charge transporting material DOW CORNING ASIA, Ltd. (JP) 1997-05-07 EP disclosed