SCHEMBL7148568

SCHEMBL7148568

COc1ccc2c(c1)CCC(CCCCC(=O)NO)C2=O.O=C(CCCCCC1CCc2cc(Cl)ccc2C1=O)NO

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP24A1 Q07973 6/20 0.49
CYP26A1 O43174 3/20 0.49
CYP27A1 Q02318 3/20 0.48
CYP19A1 P11511 1/20 0.47
ACHE P22303 4/20 0.46
HDAC8 Q9BY41 4/20 0.44
HDAC1 Q13547 4/20 0.44
NQO2 P16083 1/20 0.43
MTNR1A P48039 1/20 0.43
MTNR1B P49286 1/20 0.43
THRA P10827 1/20 0.43
THRB P10828 1/20 0.43
HDAC3 O15379 2/20 0.42
HDAC2 Q92769 2/20 0.42
HDAC10 Q969S8 2/20 0.42
HDAC11 Q96DB2 2/20 0.42
HDAC6 Q9UBN7 2/20 0.42
HDAC5 Q9UQL6 2/20 0.42
HDAC4 P56524 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7164574 0.93 CYP24A1 (0.55) CYP24A1CYP26A1CYP27A1CYP19A1HDAC8
SCHEMBL7164822 0.91 HDAC8 (0.44) CYP26A1HDAC8HDAC1HDAC3HDAC2
SCHEMBL7228543 0.85 CYP19A1 (0.53) CYP24A1CYP26A1CYP19A1HDAC8HDAC1
SCHEMBL7166421 0.82 CYP24A1 (0.61) CYP24A1CYP26A1CYP27A1CYP19A1ACHE
SCHEMBL7171258 0.79 CYP26A1 (0.47) CYP24A1CYP26A1CYP19A1
SCHEMBL7171991 0.79 HDAC6 (0.51) ACHEHDAC8HDAC1NQO2MTNR1A
SCHEMBL4623118 0.78 CYP24A1 (0.63) CYP24A1CYP26A1CYP27A1CYP19A1ACHE
SCHEMBL7167104 0.78 CYP24A1 (0.55) CYP24A1CYP26A1CYP27A1CYP19A1ACHE
SCHEMBL7163249 0.76 HDAC1 (0.50) CYP19A1HDAC8HDAC1HDAC3HDAC2
SCHEMBL4621209 0.76 CYP24A1 (0.65) CYP24A1CYP26A1CYP27A1CYP19A1ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1349830-A1 TETRALONE DERIVATIVES AS ANTITUMOR AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2003-10-08 EP claimed
WO-2002046144-A1 TETRALONE DERIVATIVES AS ANTITUMOR AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2002-06-13 WO claimed