Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP24A1 | Q07973 | 6/20 | 0.55 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.55 |
| ▸ | CYP27A1 | Q02318 | 3/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | NQO2 | P16083 | 4/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7148568 | 0.93 | CYP24A1 (0.49) | CYP24A1CYP26A1CYP27A1CYP19A1NQO2 | |
| SCHEMBL7228543 | 0.91 | CYP19A1 (0.53) | CYP24A1CYP26A1CYP19A1NQO2MTNR1A | |
| SCHEMBL7166421 | 0.88 | CYP24A1 (0.61) | CYP24A1CYP26A1CYP27A1CYP19A1THRA | |
| SCHEMBL7171991 | 0.84 | HDAC6 (0.51) | NQO2MTNR1AMTNR1BHDAC8HDAC1 | |
| SCHEMBL4623118 | 0.84 | CYP24A1 (0.63) | CYP24A1CYP26A1CYP27A1CYP19A1THRA | |
| SCHEMBL7167104 | 0.83 | CYP24A1 (0.55) | CYP24A1CYP26A1CYP27A1CYP19A1 | |
| SCHEMBL7164822 | 0.82 | HDAC8 (0.44) | CYP26A1HDAC8HDAC1HDAC3HDAC4 | |
| SCHEMBL4621209 | 0.82 | CYP24A1 (0.65) | CYP24A1CYP26A1CYP27A1CYP19A1METAP1 | |
| SCHEMBL4853888 | 0.81 | CYP24A1 (0.65) | CYP24A1CYP26A1CYP27A1CYP19A1THRA | |
| SCHEMBL7163249 | 0.79 | HDAC1 (0.50) | CYP19A1HDAC8HDAC1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6531472-B2 | Has histone deacetylase (HDAC) inhibitory activity which is useful in cancer treatment | HOFFMAN-LA ROCHE INC. | 2003-03-11 | — | — | US | claimed |
| US-20020065282-A1 | Tetralone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-30 | — | — | US | claimed |
| EP-1349830-A1 | TETRALONE DERIVATIVES AS ANTITUMOR AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-08 | — | — | EP | disclosed |
| US-6531472-B2 | Has histone deacetylase (HDAC) inhibitory activity which is useful in cancer treatment | HOFFMAN-LA ROCHE INC. | 2003-03-11 | — | — | US | disclosed |
| WO-2002046144-A1 | TETRALONE DERIVATIVES AS ANTITUMOR AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-13 | — | — | WO | disclosed |
| US-20020065282-A1 | Tetralone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020065282-A1 | Tetralone derivatives | HDAC1, HDAC5, HDAC3 | CYP24A1 1843/4885CYP26A1 1276/4885CYP27A1 2555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.