Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 9/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7165497 | 0.86 | HDAC1 (0.40) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL27582477 | 0.86 | CYP19A1 (0.52) | CYP19A1HTR2CALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL7167409 | 0.84 | CYP19A1 (0.53) | CYP19A1HTR2CALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL7164822 | 0.83 | HDAC8 (0.44) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL7164517 | 0.82 | DRD2 (0.46) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL11156946 | 0.81 | CYP19A1 (0.48) | CYP19A1HTR2CALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL8536795 | 0.80 | CYP19A1 (0.54) | CYP19A1HTR2CALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL7164574 | 0.79 | CYP24A1 (0.55) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL7168151 | 0.79 | HDAC1 (0.46) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL7228543 | 0.79 | CYP19A1 (0.53) | HDAC1HDAC8HDAC6HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6531472-B2 | Has histone deacetylase (HDAC) inhibitory activity which is useful in cancer treatment | HOFFMAN-LA ROCHE INC. | 2003-03-11 | — | — | US | claimed |
| US-20020065282-A1 | Tetralone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-30 | — | — | US | claimed |
| EP-1349830-A1 | TETRALONE DERIVATIVES AS ANTITUMOR AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-08 | — | — | EP | disclosed |
| US-6531472-B2 | Has histone deacetylase (HDAC) inhibitory activity which is useful in cancer treatment | HOFFMAN-LA ROCHE INC. | 2003-03-11 | — | — | US | disclosed |
| WO-2002046144-A1 | TETRALONE DERIVATIVES AS ANTITUMOR AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-13 | — | — | WO | disclosed |
| US-20020065282-A1 | Tetralone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020065282-A1 | Tetralone derivatives | HDAC1, HDAC5, HDAC3 | HDAC1 1/4885HDAC8 5/4885HDAC6 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.