Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143246 | 0.90 | ALDH1A1 (0.45) | MAPK1LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7146607 | 0.90 | MAPT (0.44) | MAPK1ALDH1A1MAPTSMN1; SMN2GAA | |
| SCHEMBL7142183 | 0.87 | MAPT (0.38) | MAPK1LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7143311 | 0.87 | ALDH1A1 (0.46) | MAPK1LMNAALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7142608 | 0.87 | MAPT (0.35) | MAPK1LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7139645 | 0.86 | MAPT (0.43) | MAPK1LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7148217 | 0.86 | WDR5 (0.37) | MAPK1LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7139725 | 0.85 | ALDH1A1 (0.47) | LMNAALDH1A1MAPTSMN1; SMN2GAA | |
| SCHEMBL7139736 | 0.84 | MAPT (0.40) | MAPK1LMNAALDH1A1MAPTNPSR1 | |
| SCHEMBL7141821 | 0.83 | MAPT (0.39) | MAPK1LMNAALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-B1 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6407094-B1 | 4-5-DIDEHYDRO-1,5-BENZODIAZEPIN-2-ONE DERIVATIVES; PSYCHOLOGICAL, NERVOUS SYSTEM, AND BRAIN DISORDERS; COGNITION ACTIVATORS; ALZHEIMER*S DISEASE, SCHIZOPHRENIA | HOFFMANN-LA ROCHE INC. | 2002-06-18 | — | — | US | disclosed |