Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 9/20 | 0.41 |
| ▸ | PDE4A | P27815 | 7/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.37 |
| ▸ | QPCT | Q16769 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7144111 | 0.77 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7325457 | 0.76 | PDE4B (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7150868 | 0.76 | PDE4B (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7144848 | 0.73 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DQPCT | |
| SCHEMBL7318151 | 0.71 | PDE4B (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7146511 | 0.70 | PDE4B (0.59) | PDE4B | |
| SCHEMBL7148096 | 0.69 | PDE4B (0.40) | ACACBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7610852 | 0.69 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7315822 | 0.67 | PDE4B (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7321805 | 0.67 | PDE4B (0.48) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656959-B1 | PDE IV inhibiting pyridine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-12-02 | — | — | US | disclosed |
| EP-1068194-B1 | PDE IV INHIBITING PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-11-05 | — | — | EP | disclosed |