Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.40 |
| ▸ | ACACB | O00763 | 7/20 | 0.38 |
| ▸ | PDE4A | P27815 | 6/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7148673 | 0.69 | ACACB (0.41) | PDE4BACACBPDE4APDE4CPDE4D | |
| SCHEMBL7311861 | 0.69 | PDE4A (0.56) | PDE4BPDE4APDE4CPDE4DEPHX2 | |
| SCHEMBL7149989 | 0.63 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DEPHX2 | |
| SCHEMBL7144111 | 0.62 | PDE4A (0.36) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1787764 | 0.61 | ALDH1A1 (0.51) | — | |
| SCHEMBL8462846 | 0.61 | PDE4A (0.66) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL72687 | 0.61 | PDE4D (0.68) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3574564 | 0.60 | L3MBTL1 (0.42) | — | |
| SCHEMBL1353554 | 0.60 | ALDH1A1 (0.54) | — | |
| SCHEMBL3969483 | 0.59 | MTNR1A (0.54) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656959-B1 | PDE IV inhibiting pyridine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-12-02 | — | — | US | disclosed |
| EP-1068194-B1 | PDE IV INHIBITING PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-11-05 | — | — | EP | disclosed |