Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.39 |
| ▸ | PDE4A | P27815 | 5/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.39 |
| ▸ | CNR2 | P34972 | 10/20 | 0.39 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7619551 | 0.83 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7357472 | 0.78 | PDE4B (0.41) | PDE4BCNR2TRPC6 | |
| SCHEMBL7148906 | 0.77 | PDE4B (0.42) | PDE4BPDE4APDE4DTRPC6 | |
| SCHEMBL7148673 | 0.76 | ACACB (0.41) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL71158 | 0.71 | TRPC6 (0.48) | PDE4BPDE4APDE4CPDE4DCNR2 | |
| SCHEMBL88281 | 0.70 | TRPC6 (0.49) | PDE4BPDE4APDE4CPDE4DCNR2 | |
| SCHEMBL18708221 | 0.70 | TRPC6 (0.49) | PDE4BPDE4APDE4CPDE4DCNR2 | |
| SCHEMBL3633786 | 0.69 | TRPC6 (0.54) | PDE4BPDE4APDE4CPDE4DCNR2 | |
| SCHEMBL7614635 | 0.69 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7151008 | 0.68 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656959-B1 | PDE IV inhibiting pyridine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-12-02 | — | — | US | disclosed |
| EP-1068194-B1 | PDE IV INHIBITING PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-11-05 | — | — | EP | disclosed |