Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2539677 | 0.70 | CHRNB2 (0.39) | CHRNB2CHRNA4HCAR2ALDH1A1CHRNB4 | |
| SCHEMBL197007 | 0.69 | — | — | |
| SCHEMBL7237495 | 0.69 | — | — | |
| SCHEMBL197006 | 0.69 | — | — | |
| SCHEMBL8555916 | 0.69 | HCAR2 (0.40) | CHRNB2CHRNA4HCAR2ALDH1A1LMNA | |
| SCHEMBL28699965 | 0.69 | — | — | |
| SCHEMBL8773021 | 0.68 | CHRNB2 (0.39) | CHRNB2CHRNA4HCAR2ALDH1A1CHRNB4 | |
| SCHEMBL11030932 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL217260 | 0.67 | HCAR2 (0.39) | CHRNB2CHRNA4HCAR2ALDH1A1CHRNB4 | |
| Hydrochloric Acid SCHEMBL7237491 | 0.67 | HCAR2 (0.39) | CHRNB2CHRNA4HCAR2ALDH1A1CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525059-B1 | Mitogen-activated protein kinases (MAP); | G. D. SEARLE & COMPANY | 2003-02-25 | — | — | US | disclosed |