Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7043536 | 0.89 | MAPT (0.48) | KDM4EALDH1A1HPGDNPSR1SMN1; SMN2 | |
| SCHEMBL7147869 | 0.88 | NPC1 (0.56) | KDM4EALDH1A1HPGDNPSR1SMN1; SMN2 | |
| SCHEMBL7042535 | 0.87 | CYP1A2 (0.44) | KDM4EALDH1A1HPGDNPSR1SMN1; SMN2 | |
| SCHEMBL7041864 | 0.85 | HDAC6 (0.44) | KDM4EALDH1A1HPGDNPSR1SMN1; SMN2 | |
| SCHEMBL7041685 | 0.84 | GABRD (0.47) | KDM4EALDH1A1HPGDNPSR1SMN1; SMN2 | |
| SCHEMBL7146666 | 0.83 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDNPSR1SMN1; SMN2 | |
| SCHEMBL7042500 | 0.83 | MAPT (0.46) | KDM4EALDH1A1HPGDNPSR1SMN1; SMN2 | |
| SCHEMBL7151229 | 0.80 | KMT2A (0.51) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL7145678 | 0.78 | MAPT (0.44) | KDM4EALDH1A1HPGDNPSR1SMN1; SMN2 | |
| SCHEMBL7143995 | 0.74 | ADORA1 (0.53) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |