Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7699823 | 0.82 | HTT (0.37) | MAOAMAOBACSL1GAAKDM4E | |
| SCHEMBL7594758 | 0.81 | TYMS (0.36) | MAOAMAOBKLK5 | |
| SCHEMBL7369195 | 0.78 | MAOA (0.46) | MAOAMAOBGAANPSR1 | |
| SCHEMBL1925024 | 0.76 | MAOA (0.41) | MAOAMAOBACSL1GAANPSR1 | |
| SCHEMBL5929681 | 0.75 | MAOA (0.43) | MAOAMAOBGAANPSR1 | |
| SCHEMBL30920096 | 0.75 | MAOA (0.43) | MAOAMAOBGAAKDM4EALDH1A1 | |
| SCHEMBL6532527 | 0.75 | MAOA (0.43) | MAOAMAOBGAANPSR1 | |
| SCHEMBL7868192 | 0.75 | MAOA (0.39) | MAOAMAOBGAANPSR1 | |
| SCHEMBL30505283 | 0.74 | MAOA (0.42) | MAOAMAOBACSL1GAAKDM4E | |
| SCHEMBL990074 | 0.74 | MAOA (0.42) | MAOAMAOBACSL1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977748-B1 | SUBSTITUTED BENZOPYRAN DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2003-03-26 | — | — | EP | claimed |
| EP-0325954-A3 | PROCESS FOR THE PREPARATION OF OPTICALLY PURE HYDROXY-SUBSTITUTED BENZOPYRANCARBONIC ACIDS AND ESTERS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-01-09 | — | — | EP | disclosed |
| EP-0325954-A2 | Process for the preparation of optically pure hydroxy-substituted benzopyrancarbonic acids and esters | F. HOFFMANN-LA ROCHE AG (CH) | 1989-08-02 | — | — | EP | disclosed |