Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.49 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7146843 | 0.91 | LMNA (0.49) | KDM4EMAPTLMNAPDE4DADCY1 | |
| SCHEMBL7039193 | 0.91 | LMNA (0.61) | KDM4EMAPTLMNAPDE4DJAK2 | |
| SCHEMBL7140763 | 0.90 | MAPT (0.68) | KDM4EMAPTLMNAPDE4DJAK1 | |
| SCHEMBL7145623 | 0.89 | LMNA (0.48) | KDM4EMAPTLMNAPDE4DJAK2 | |
| SCHEMBL7151579 | 0.85 | LMNA (0.46) | KDM4EMAPTLMNAPDE4DJAK2 | |
| SCHEMBL7145859 | 0.84 | JAK2 (0.54) | KDM4EMAPTLMNAPDE4DJAK1 | |
| SCHEMBL7143968 | 0.83 | LMNA (0.47) | KDM4EMAPTLMNAJAK1JAK2 | |
| SCHEMBL6870164 | 0.83 | KDM4E (0.58) | KDM4EMAPTLMNAPDE4DJAK2 | |
| SCHEMBL6871008 | 0.82 | JAK2 (0.51) | KDM4EMAPTLMNAPDE4DJAK2 | |
| SCHEMBL7042283 | 0.80 | MAPT (0.56) | KDM4EMAPTLMNAPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |