Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.57 |
| ▸ | NOS2 | P35228 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7154078 | 0.82 | RAB9A (0.61) | NOS1NOS2MAPTRAB9ANPSR1 | |
| SCHEMBL7147166 | 0.81 | MAOB (0.59) | NOS1NOS2MAPTRAB9ANPSR1 | |
| SCHEMBL9791457 | 0.79 | MAPT (0.61) | NOS1NOS2MAPTRAB9ANPSR1 | |
| SCHEMBL16047069 | 0.77 | MAOB (0.44) | NOS1NOS2LRRK2MAOBMAOA | |
| SCHEMBL30150593 | 0.76 | RAB9A (0.62) | NOS1NOS2MAPTRAB9ANPSR1 | |
| SCHEMBL1323646 | 0.76 | RAB9A (0.62) | NOS1NOS2MAPTRAB9ANPSR1 | |
| SCHEMBL24932986 | 0.76 | RAB9A (0.61) | NOS1NOS2MAPTRAB9ANPSR1 | |
| SCHEMBL30896277 | 0.76 | RAB9A (0.61) | NOS1NOS2MAPTRAB9ANPSR1 | |
| SCHEMBL12292103 | 0.76 | RAB9A (0.61) | NOS1NOS2MAPTRAB9ANPSR1 | |
| SCHEMBL27625101 | 0.76 | MAPT (0.61) | NOS1NOS2MAPTRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6667327-B2 | Pyridine amido derivatives | HOFFMANN-LA ROCHE INC. | 2003-12-23 | — | — | US | disclosed |