Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7149424 | 1.00 | MCL1 (0.46) | MCL1AKR1C3AKR1C1MEN1KMT2A | |
| SCHEMBL4649014 | 0.85 | AKR1C3 (0.47) | MCL1AKR1C3AKR1C1MEN1KMT2A | |
| SCHEMBL4649011 | 0.85 | AKR1C3 (0.47) | MCL1AKR1C3AKR1C1MEN1KMT2A | |
| SCHEMBL7153123 | 0.85 | AKR1C3 (0.47) | MCL1AKR1C3AKR1C1MEN1KMT2A | |
| SCHEMBL10697896 | 0.83 | MCL1 (0.41) | MCL1AKR1C3AKR1C1MEN1KMT2A | |
| SCHEMBL28723296 | 0.79 | MEN1 (0.44) | AKR1C3MEN1KMT2ARECQLABCG2 | |
| SCHEMBL4725824 | 0.78 | MEN1 (0.42) | AKR1C3AKR1C1MEN1KMT2AFBP1 | |
| SCHEMBL4725821 | 0.78 | MEN1 (0.42) | AKR1C3AKR1C1MEN1KMT2AFBP1 | |
| SCHEMBL7672337 | 0.78 | ABCG2 (0.51) | MCL1AKR1C3AKR1C1MEN1KMT2A | |
| SCHEMBL20596721 | 0.77 | MCL1 (0.45) | MCL1AKR1C3AKR1C1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309590-A1 | AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2003-05-14 | — | — | EP | disclosed |
| WO-2001098299-A1 | AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | disclosed |