Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 16/20 | 0.77 |
| ▸ | CTSS | P25774 | 9/20 | 0.58 |
| ▸ | CTSL | P07711 | 6/20 | 0.58 |
| ▸ | CTSV | O60911 | 3/20 | 0.58 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.52 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452158 | 1.00 | CTSK (0.77) | CTSKCTSSCTSLCTSVTAS1R3 | |
| SCHEMBL4458887 | 1.00 | CTSK (0.77) | CTSKCTSSCTSLCTSVTAS1R3 | |
| SCHEMBL13677177 | 1.00 | CTSK (0.77) | CTSKCTSSCTSLCTSVTAS1R3 | |
| SCHEMBL4449567 | 0.95 | CTSK (0.69) | CTSKCTSSCTSLCTSVTAS1R3 | |
| SCHEMBL4455830 | 0.90 | CTSK (0.62) | CTSKCTSSCTSLCTSVTAS1R3 | |
| SCHEMBL4455880 | 0.89 | CTSS (0.71) | CTSKCTSSCTSLCTSVTAS1R3 | |
| SCHEMBL8230139 | 0.89 | CTSK (0.79) | CTSKCTSSCTSLCTSV | |
| SCHEMBL4452702 | 0.89 | CTSK (0.82) | CTSKCTSSCTSLCTSV | |
| SCHEMBL5259245 | 0.89 | CTSK (0.82) | CTSKCTSSCTSLCTSV | |
| SCHEMBL13677272 | 0.89 | CTSK (0.82) | CTSKCTSSCTSLCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |