Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.60 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PPARD | Q03181 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11537116 | 0.87 | HSD17B10 (0.61) | GLAKMT2AMEN1NPC1TLR9 | |
| SCHEMBL10796884 | 0.86 | KMT2A (0.63) | GLAKMT2AMEN1NPC1TLR9 | |
| SCHEMBL10601959 | 0.84 | HSD17B10 (0.73) | KMT2AMEN1NPC1TLR9HSD17B10 | |
| SCHEMBL19411347 | 0.82 | HSD17B10 (0.53) | GLAKMT2AMEN1NPC1TLR9 | |
| SCHEMBL9516311 | 0.81 | HSD17B10 (0.77) | KMT2AMEN1SCN2ANPSR1CA9 | |
| SCHEMBL27264218 | 0.80 | KMT2A (0.53) | KMT2AMEN1SCN2ACA9CA12 | |
| SCHEMBL14877657 | 0.80 | MEN1 (0.52) | GLAKMT2AMEN1NPC1TLR9 | |
| SCHEMBL2550387 | 0.79 | NR1H3 (0.81) | KMT2AMEN1NPC1SCN2ANR1H3 | |
| SCHEMBL3408445 | 0.78 | KMT2A (0.66) | KMT2AMEN1SCN2ACA9CA12 | |
| SCHEMBL14877640 | 0.78 | HSD17B10 (0.58) | GLAKMT2AMEN1NPC1TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076644-B1 | N-SUBSTITUTED AMINOTETRALINS AS LIGANDS FOR THE NEUROPEPTIDE Y Y5 RECEPTOR USEFUL IN THE TREATMENT OF OBESITY AND OTHER DISORDERS | ORTHO MCNEIL PHARM INC (US) | 2004-06-23 | — | — | EP | disclosed |
| EP-1076644-A1 | N-SUBSTITUTED AMINOTETRALINS AS LIGANDS FOR THE NEUROPEPTIDE Y Y5 RECEPTOR USEFUL IN THE TREATMENT OF OBESITY AND OTHER DISORDERS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6140354-A | FOR TREATMENT OF DISORDERS OR DISEASE STATES CAUSED BY EATING DISORDERS, OBESITY, BULIMIA NERVOSA, DIABETES, HYPERTENSION, MEMORY LOSS, EPILEPTIC SEIZURES, MIGRAINE, SLEEP DISTURBANCES, PAIN, SEXUAL/REPRODUCTIVE DISORDERS, DEPRESSION | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-10-31 | — | — | US | disclosed |
| WO-1999055667-A1 | N-SUBSTITUTED AMINOTETRALINS AS LIGANDS FOR THE NEUROPEPTIDE Y Y5 RECEPTOR USEFUL IN THE TREATMENT OF OBESITY AND OTHER DISORDERS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-11-04 | — | — | WO | disclosed |
| EP-0161413-B1 | WHOLLY AROMATIC POLYESTERS, PROCESS FOR THEIR PREPARATION AND SHAPED ARTICLES MADE THEREFROM | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-01-18 | — | — | EP | disclosed |
| US-4661579-A | Completely aromatic polyesters, a process for their preparation and corresponding shaped articles | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-04-28 | — | — | US | disclosed |
| EP-0161413-A1 | Wholly aromatic polyesters, process for their preparation and shaped articles made therefrom | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-11-21 | — | — | EP | disclosed |