Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 2/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019626 | 0.81 | GSK3B (0.54) | CYP2D6MAPTNPSR1NCOA1NCOA3 | |
| SCHEMBL4395953 | 0.80 | GSK3B (0.51) | MAPTNPSR1CCNB2CDK1CCNB1 | |
| SCHEMBL5101039 | 0.76 | GSK3B (0.44) | CYP2D6NPSR1GHSRCCNB2CDK1 | |
| SCHEMBL7146357 | 0.71 | GSK3B (0.37) | CYP2D6NPSR1CCNB2CDK1CCNB1 | |
| SCHEMBL2909547 | 0.69 | GSK3B (0.37) | CYP2D6CCNB2CDK1CCNB1GSK3A | |
| SCHEMBL4992908 | 0.69 | GSK3B (0.53) | MAPTNPSR1CCNB2CDK1CCNB1 | |
| Hydrochloric Acid SCHEMBL2911853 | 0.69 | KAT2B (0.37) | CYP2D6CCNB2CDK1CCNB1GSK3A | |
| SCHEMBL4395954 | 0.68 | GSK3B (0.69) | CYP2D6CCNB2CDK1CCNB1GSK3A | |
| SCHEMBL7025860 | 0.68 | MAPT (0.36) | MAPTNPSR1CCNB2CDK1CCNB1 | |
| SCHEMBL4393950 | 0.68 | GSK3B (0.50) | MAPTNPSR1CCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |