SCHEMBL7152117

SCHEMBL7152117

CC#CCN(CC)CCO

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.41
CYP2C9 P11712 1/20 0.41
HPGD P15428 1/20 0.41
MAPK1 P28482 1/20 0.41
HIF1A Q16665 1/20 0.41
HSD17B10 Q99714 1/20 0.41
CHRM2 P08172 2/20 0.38
CHRM4 P08173 2/20 0.38
CHRM5 P08912 2/20 0.38
CHRM1 P11229 2/20 0.38
CHRM3 P20309 2/20 0.38
KCNH2 Q12809 10/20 0.35
CYP2D6 P10635 1/20 0.35
LSS P48449 1/20 0.34
MAPT P10636 1/20 0.31
ALDH1A1 P00352 1/20 0.30
ALDH2 P05091 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7704607 0.88 MAPT (0.35) CYP1A2CYP2C9HPGDMAPK1HIF1A
SCHEMBL8335192 0.87 KCNH2 (0.38) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL20835285 0.84 MAPT (0.32) MAPT
SCHEMBL936173 0.80
SCHEMBL5738098 0.74
SCHEMBL5730528 0.74
Diethylaminoethanol SCHEMBL3114 0.74
SCHEMBL35602 0.74
Diethylaminoethanol SCHEMBL10699915 0.74
SCHEMBL7149710 0.74 KCNH2 (0.33) CHRM2CHRM4CHRM5CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1334094-A1 CHOLESTEROL LOWERING BENZO[B]THIOPHENES AND BENZO[D]ISOTHIAZOLES F. HOFFMANN-LA ROCHE AG (CH) 2003-08-13 EP disclosed
WO-2002036584-A1 CHOLESTEROL LOWERING BENZO`B! THIOPHENES AND BENZO`D! ISOTHIAZOLES F. HOFFMANN-LA ROCHE AG (CH) 2002-05-10 WO disclosed
EP-0915826-A4 SMOOTH MUSCLE SPASMOLYTIC AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF BRIDGE PHARMA INC (US) 1999-12-29 EP disclosed
EP-0915826-A1 SMOOTH MUSCLE SPASMOLYTIC AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF Bridge Pharma, Inc. (US) 1999-05-19 EP disclosed
WO-1998000390-A1 SMOOTH MUSCLE SPASMOLYTIC AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF BRIDGE PHARMA, INC. (US) 1998-01-08 WO disclosed