SCHEMBL715253

SCHEMBL715253

CC(=O)Oc1cc(/C=C/c2cc(OC(C)=O)cc(OC(C)=O)c2)cc(OC(C)=O)c1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.81
MAPT P10636 3/20 0.81
TTR P02766 3/20 0.81
CYP3A4 P08684 2/20 0.81
KDM4E B2RXH2 2/20 0.81
MEN1 O00255 2/20 0.81
KMT2A Q03164 2/20 0.81
TP53 P04637 1/20 0.81
SMN1; SMN2 Q16637 1/20 0.81
CYP19A1 P11511 2/20 0.73
TUBB4A P04350 3/20 0.53
TUBB P07437 3/20 0.53
TUBA3C P0DPH7 3/20 0.53
TUBA1B P68363 3/20 0.53
TUBA4A P68366 3/20 0.53
TUBB4B P68371 3/20 0.53
TUBB3 Q13509 3/20 0.53
TUBB2A Q13885 3/20 0.53
TUBB8 Q3ZCM7 3/20 0.53
TUBA3E Q6PEY2 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL715254 1.00 LMNA (0.81) LMNAMAPTTTRCYP3A4KDM4E
Triacetylresveratrol SCHEMBL717979 0.90 TTR (1.00) LMNAMAPTTTRCYP3A4KDM4E
SCHEMBL10149312 0.90 LMNA (0.69) LMNAMAPTTTRCYP3A4KDM4E
SCHEMBL10149318 0.90 LMNA (0.69) LMNAMAPTTTRCYP3A4KDM4E
Triacetylresveratrol SCHEMBL717980 0.90 TTR (1.00) LMNAMAPTTTRCYP3A4KDM4E
SCHEMBL718478 0.89 KMT2A (0.77) LMNAMAPTTTRCYP3A4KDM4E
SCHEMBL718479 0.89 KMT2A (0.77) LMNAMAPTTTRCYP3A4KDM4E
SCHEMBL715257 0.87 KDM4E (0.65) LMNAMAPTTTRCYP3A4KDM4E
SCHEMBL1810217 0.87 KDM4E (0.81) LMNAMAPTTTRCYP3A4KDM4E
SCHEMBL10148966 0.87 MAPT (0.81) LMNAMAPTTTRCYP3A4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200188878-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2020-06-18 US disclosed
US-20200188878-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2020-06-18 US disclosed
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2016-10-06 US disclosed
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2016-10-06 US disclosed
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2012-03-01 US disclosed
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2012-03-01 US disclosed
WO-2010085851-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2010-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 LMNA 3479/4885MAPT 3368/4885TTR 4880/4885
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 LMNA 3479/4885MAPT 3368/4885TTR 4880/4885
US-20200188878-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 LMNA 3479/4885MAPT 3368/4885TTR 4880/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.