SCHEMBL10148966

SCHEMBL10148966

CC(=O)Oc1cc(/C=C/c2ccc(C)cc2)cc(OC(C)=O)c1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.81
LMNA P02545 3/20 0.81
TTR P02766 3/20 0.81
KDM4E B2RXH2 2/20 0.81
MEN1 O00255 2/20 0.81
KMT2A Q03164 2/20 0.81
TP53 P04637 1/20 0.81
CYP3A4 P08684 1/20 0.81
SMN1; SMN2 Q16637 1/20 0.81
CYP19A1 P11511 2/20 0.73
TUBB4A P04350 4/20 0.55
TUBB P07437 4/20 0.55
TUBA3C P0DPH7 4/20 0.55
TUBA1B P68363 4/20 0.55
TUBA4A P68366 4/20 0.55
TUBB4B P68371 4/20 0.55
TUBB3 Q13509 4/20 0.55
TUBB2A Q13885 4/20 0.55
TUBB8 Q3ZCM7 4/20 0.55
TUBA3E Q6PEY2 4/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13259325 0.93 LMNA (0.71) MAPTLMNATTRKDM4EMEN1
SCHEMBL8206264 0.91 LMNA (0.68) MAPTLMNATTRKDM4EMEN1
SCHEMBL8206260 0.91 LMNA (0.68) MAPTLMNATTRKDM4EMEN1
Triacetylresveratrol SCHEMBL717980 0.89 TTR (1.00) MAPTLMNATTRKDM4EMEN1
Triacetylresveratrol SCHEMBL717979 0.89 TTR (1.00) MAPTLMNATTRKDM4EMEN1
SCHEMBL715254 0.87 LMNA (0.81) MAPTLMNATTRKDM4EMEN1
SCHEMBL715253 0.87 LMNA (0.81) MAPTLMNATTRKDM4EMEN1
SCHEMBL13259327 0.87 LMNA (0.81) MAPTLMNATTRKDM4EMEN1
SCHEMBL1810217 0.86 KDM4E (0.81) MAPTLMNATTRKDM4EMEN1
SCHEMBL6847961 0.86 KDM4E (0.81) MAPTLMNATTRKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12029706-B2 Methods for treating mucopolysaccharidosis UNIVERSITY OF MIAMI (US) 2024-07-09 US disclosed
US-20180221303-A1 PERITONEAL THERAPEUTIC FLUID OPTERION HEALTH AG (CH) 2018-08-09 US disclosed
US-20180214387-A1 AQUEOUS SOLUTION COMPRISING A POLYPHENOL OPTERION HEALTH AG (CH) 2018-08-02 US disclosed
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2016-10-06 US disclosed
US-8912234-B2 Composition containing resveratrol and/or derivatives thereof and plant oil, process for producing said composition, nutraceutical and/or pharmaceutical product, and method for enhancing the potential of resveratrol UNIAO Brasileria de Educacao e Assistencia—Mantenedora da PUCRS (BR) 2014-12-16 US disclosed
US-20130040920-A1 COMPOSITION CONTAINING RESVERATROL AND/OR DERIVATIVES THEREOF AND PLANT OIL, PROCESS FOR PRODUCING SAID COMPOSITION, NUTRACEUTICAL AND/OR PHARMACEUTICAL PRODUCT, AND METHOD FOR ENHANCING THE POTENTIAL OF RESVERATROL UNIAO Brasileira de Educacao e Assistencia- Matenedora da PUCRS (BR) 2013-02-14 US disclosed
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2012-03-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130040920-A1 COMPOSITION CONTAINING RESVERATROL AND/OR DERIVATIVES THEREOF AND PLANT OIL, PROCESS FOR PRODUCING SAID COMPOSITION, NUTRACEUTICAL AND/OR PHARMACEUTICAL PRODUCT, AND METHOD FOR ENHANCING THE POTENTIAL OF RESVERATROL GPR119, MAVS, SIRT1 MAPT 1683/4885LMNA 1562/4885TTR 1952/4885
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 MAPT 3368/4885LMNA 3479/4885TTR 4880/4885
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 MAPT 3368/4885LMNA 3479/4885TTR 4880/4885
US-20180214387-A1 AQUEOUS SOLUTION COMPRISING A POLYPHENOL SORD, AQP1, SI MAPT 396/4885LMNA 2253/4885TTR 220/4885
US-12029706-B2 Methods for treating mucopolysaccharidosis GAA, MAN2B1, IDUA MAPT 4009/4885LMNA 567/4885TTR 866/4885
US-20180221303-A1 PERITONEAL THERAPEUTIC FLUID FABP6, ALB, FABP2 MAPT 1954/4885LMNA 4496/4885TTR 35/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.