Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.33 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.33 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.33 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443 | 0.91 | SLC6A9 (0.40) | SLC6A9ALDH1A1CYP2C9NPC1BRD4 | |
| SCHEMBL4535 | 0.88 | GAA (0.37) | SLC6A9ALDH1A1GAACYP2C9BRD4 | |
| SCHEMBL7143 | 0.87 | LPAR1 (0.41) | SLC6A9ALDH1A1GAACYP2C9BRD4 | |
| SCHEMBL6482 | 0.86 | LPAR1 (0.41) | SLC6A9ALDH1A1GAACYP2C9BRD4 | |
| SCHEMBL7152 | 0.85 | LMNA (0.36) | ALDH1A1GAAMAPTCYP2C9NPC1 | |
| SCHEMBL3972 | 0.79 | LPAR1 (0.38) | SLC6A9ALDH1A1CYP2C9ABCC3ABCC4 | |
| SCHEMBL7296 | 0.79 | LPAR1 (0.39) | ALDH1A1GAAMAPTCYP2C9NPC1 | |
| SCHEMBL6392 | 0.78 | LPAR1 (0.40) | ALDH1A1MAPTCYP2C9NPC1BRD4 | |
| SCHEMBL6861 | 0.77 | LPAR1 (0.42) | ALDH1A1MAPTCYP2C9ABCC3ABCC4 | |
| SCHEMBL4183 | 0.77 | GAA (0.42) | ALDH1A1GAACYP2C9NPC1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |