SCHEMBL7153126

SCHEMBL7153126

O=C(O)C=C(OC(F)(F)F)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 3/20 0.44
PDPK1 O15530 1/20 0.41
NR4A1 P22736 1/20 0.39
NR4A2 P43354 1/20 0.39
NR4A3 Q92570 1/20 0.39
NFE2L2 Q16236 1/20 0.38
F2 P00734 1/20 0.38
LMNA P02545 1/20 0.38
ALDH1A1 P00352 3/20 0.37
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA9 Q16790 1/20 0.37
TSHR P16473 3/20 0.37
CES2 O00748 2/20 0.37
DAO P14920 1/20 0.37
NAPRT Q6XQN6 1/20 0.37
MAPK1 P28482 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
AKT1 P31749 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7797898 0.86 CES1 (0.41) CES1NR4A1NR4A2NR4A3NFE2L2
SCHEMBL7149425 0.86 CES1 (0.41) CES1NFE2L2F2LMNAALDH1A1
SCHEMBL3189100 0.75 TSHR (0.59) CES1NFE2L2F2LMNAALDH1A1
SCHEMBL1536367 0.75 TSHR (0.59) CES1NFE2L2F2LMNAALDH1A1
SCHEMBL1536368 0.75 TSHR (0.59) CES1NFE2L2F2LMNAALDH1A1
SCHEMBL219676 0.74 LMNA (0.56) CES1F2LMNAALDH1A1TSHR
SCHEMBL28123902 0.72 LMNA (0.54) CES1F2LMNAALDH1A1TSHR
Hydrochloric Acid SCHEMBL6620902 0.72 LMNA (0.54) CES1F2LMNAALDH1A1TSHR
SCHEMBL11421432 0.72 ELANE (0.43) CES1NFE2L2F2LMNAALDH1A1
SCHEMBL11421430 0.72 ELANE (0.43) CES1NFE2L2F2LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1309590-A1 AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS Pharmacia Italia S.p.A. (IT) 2003-05-14 EP disclosed
WO-2001098299-A1 AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA S.P.A. (IT) 2001-12-27 WO disclosed