SCHEMBL7153179

SCHEMBL7153179

CCOC(=O)c1ccc(NC(=O)c2ccc(OC)c(NCc3cccs3)c2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.57
NPC1 O15118 4/20 0.57
MAPT P10636 11/20 0.57
ALDH1A1 P00352 2/20 0.57
MAPK1 P28482 2/20 0.57
LMNA P02545 2/20 0.56
POLB P06746 3/20 0.56
THRB P10828 2/20 0.56
MEN1 O00255 6/20 0.51
KMT2A Q03164 6/20 0.51
GAA P10253 2/20 0.51
SMN1; SMN2 Q16637 4/20 0.50
HPGD P15428 2/20 0.49
KDM4E B2RXH2 1/20 0.49
TSHR P16473 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
HTT P42858 1/20 0.47
CASP3 P42574 1/20 0.47
SENP8 Q96LD8 1/20 0.47
SENP7 Q9BQF6 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7149497 0.92 MAPK1 (0.58) RAB9ANPC1MAPTALDH1A1MAPK1
SCHEMBL7857656 0.88 MAPT (0.55) RAB9AMAPTALDH1A1LMNAPOLB
SCHEMBL7152820 0.88 HDAC8 (0.56) MAPTALDH1A1POLBTHRBMEN1
SCHEMBL7147183 0.87 MAPT (0.54) RAB9AMAPTALDH1A1MAPK1LMNA
SCHEMBL7155890 0.83 MAPT (0.50) RAB9AMAPTALDH1A1MAPK1LMNA
SCHEMBL7154583 0.83 MAPT (0.55) RAB9ANPC1MAPTALDH1A1LMNA
SCHEMBL7150679 0.82 KMT2A (0.50) RAB9AMAPTALDH1A1MAPK1LMNA
SCHEMBL7154797 0.82 MAPT (0.58) RAB9ANPC1MAPTALDH1A1LMNA
SCHEMBL7151899 0.81 LMNA (0.62) RAB9ANPC1ALDH1A1MAPK1LMNA
SCHEMBL11420546 0.80 RAB9A (0.69) RAB9ANPC1MAPTALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1042276-A1 THIOUREA COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING OR PREVENTING INFLAMMATORY DISEASES AND ATHEROSCLEROSIS WARNER-LAMBERT COMPANY LLC (US) 2000-10-11 EP claimed
WO-1999032433-A1 THIOUREA AND BENZAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING OR PREVENTING INFLAMMATORY DISEASES AND ATHEROSCLEROSIS WARNER-LAMBERT COMPANY (US) 1999-07-01 WO claimed
US-6528528-B2 Inhibitors of 15-lipoxygenase, inhibiting chemotaxis of monocytes WARNER-LAMBERT COMPANY 2003-03-04 US disclosed
US-6268387-B1 INHIBITORS OF THE ENZYME 15-LIPOXYGENASE AND ARE INHIBITORS OF MONOCYTE CHEMOTAXIS. WARNER-LAMBERT COMPANY 2001-07-31 US disclosed
EP-1042276-A1 THIOUREA COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING OR PREVENTING INFLAMMATORY DISEASES AND ATHEROSCLEROSIS WARNER-LAMBERT COMPANY LLC (US) 2000-10-11 EP disclosed
WO-1999032433-A1 THIOUREA AND BENZAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING OR PREVENTING INFLAMMATORY DISEASES AND ATHEROSCLEROSIS WARNER-LAMBERT COMPANY (US) 1999-07-01 WO disclosed