Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 17/20 | 0.62 |
| ▸ | DRD3 | P35462 | 16/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.62 |
| ▸ | HTR1A | P08908 | 9/20 | 0.59 |
| ▸ | DRD4 | P21917 | 8/20 | 0.59 |
| ▸ | HTR2A | P28223 | 8/20 | 0.59 |
| ▸ | HTR2C | P28335 | 7/20 | 0.59 |
| ▸ | HTR2B | P41595 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7056494 | 0.87 | DRD2 (0.60) | DRD2DRD3ADRA1AHTR1ADRD4 | |
| SCHEMBL7049959 | 0.85 | DRD2 (0.61) | DRD2DRD3ADRA1ADRD4MEN1 | |
| SCHEMBL7052933 | 0.83 | DRD2 (0.66) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL7057222 | 0.82 | DRD2 (0.77) | DRD2DRD3ADRA1AHTR1AHTR2A | |
| SCHEMBL7056283 | 0.82 | DRD2 (0.76) | DRD2DRD3ADRA1AHTR1ADRD4 | |
| SCHEMBL7058123 | 0.81 | DRD3 (0.71) | DRD2DRD3ADRA1AHTR1ADRD4 | |
| SCHEMBL7058078 | 0.75 | DRD2 (0.56) | DRD2DRD3ADRA1AHTR1ADRD4 | |
| SCHEMBL7055010 | 0.74 | DRD2 (0.61) | DRD2DRD3ADRA1AHTR1ADRD4 | |
| SCHEMBL7053773 | 0.74 | DRD3 (0.68) | DRD2DRD3ADRA1AHTR1ADRD4 | |
| SCHEMBL7055616 | 0.73 | DRD2 (0.67) | DRD2DRD3ADRA1AHTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028728-A1 | 4-(4-SUBSTITUTED PIPERAZINYL-1YL)-BUTYLCARBOXAMIDES AS D3 DOPAMINE SUBTYPE SELECTIVE LIGANDS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2003-04-10 | — | — | WO | disclosed |