Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | TDO2 | P48775 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7158427 | 0.81 | CASP3 (0.49) | CASP3SMN1; SMN2MAPTNPC1TP53 | |
| SCHEMBL6449089 | 0.81 | CASP3 (0.49) | CASP3SMN1; SMN2MAPTNPC1TP53 | |
| SCHEMBL6457424 | 0.78 | CASP3 (0.48) | CASP3SMN1; SMN2MAPTNPC1TP53 | |
| SCHEMBL7051693 | 0.75 | CHUK (0.68) | CASP3SMN1; SMN2MAPTNPC1TP53 | |
| SCHEMBL7153588 | 0.73 | CASP3 (0.53) | CASP3NPC1KDM4ENPSR1CHUK | |
| SCHEMBL7048686 | 0.72 | CASP3 (0.52) | CASP3NPC1RAB9ANPSR1CHUK | |
| SCHEMBL6448883 | 0.71 | CASP3 (0.48) | CASP3MAPTPKMCHUKTXNRD1 | |
| SCHEMBL7188138 | 0.71 | CASP3 (0.40) | CASP3SMN1; SMN2MAPTNPC1TP53 | |
| SCHEMBL6452503 | 0.70 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTNPC1TP53ALDH1A1 | |
| SCHEMBL6452318 | 0.70 | NPC1 (0.64) | CASP3SMN1; SMN2MAPTNPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004110351-A2 | HETEROCYCLIC COMPOUNDS FOR TREATING HEPATITIS C VIRUS | ANADYS PHARMACEUTICALS, INC. (US) | 2004-12-23 | — | — | WO | disclosed |