Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.63 |
| ▸ | NPC1 | O15118 | 8/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8526236 | 0.82 | RAB9A (0.73) | RAB9ANPC1SMN1; SMN2POLBCYP1A2 | |
| SCHEMBL30576785 | 0.81 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2CRBNPOLB | |
| SCHEMBL1713549 | 0.80 | RAB9A (0.71) | RAB9ANPC1SMN1; SMN2CRBNPOLB | |
| SCHEMBL7217567 | 0.80 | RAB9A (0.71) | RAB9ANPC1SMN1; SMN2POLBCYP1A2 | |
| SCHEMBL11783793 | 0.80 | RAB9A (0.71) | RAB9ANPC1SMN1; SMN2POLBCYP1A2 | |
| SCHEMBL692953 | 0.80 | CRBN (0.43) | RAB9ANPC1SMN1; SMN2CRBNPOLB | |
| SCHEMBL4815658 | 0.79 | CRBN (0.58) | RAB9ANPC1SMN1; SMN2CRBNPOLB | |
| SCHEMBL4815655 | 0.79 | CRBN (0.58) | RAB9ANPC1SMN1; SMN2CRBNPOLB | |
| SCHEMBL9571707 | 0.79 | RAB9A (0.69) | RAB9ANPC1SMN1; SMN2CRBNPOLB | |
| SCHEMBL29561851 | 0.79 | RAB9A (0.69) | RAB9ANPC1SMN1; SMN2CRBNPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124086-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |