SCHEMBL8526236

SCHEMBL8526236

c1ccc2sc(N3CCCC3)nc2c1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 15/20 0.73
NPC1 O15118 13/20 0.73
SMN1; SMN2 Q16637 5/20 0.73
POLB P06746 2/20 0.67
CYP1A2 P05177 1/20 0.67
CYP2D6 P10635 1/20 0.67
CYP2C9 P11712 1/20 0.67
CYP2C19 P33261 1/20 0.67
TSHR P16473 2/20 0.63
MEN1 O00255 2/20 0.63
KMT2A Q03164 2/20 0.63
NPSR1 Q6W5P4 1/20 0.63
ALDH1A1 P00352 3/20 0.61
MAPT P10636 3/20 0.61
HTT P42858 1/20 0.61
LMNA P02545 1/20 0.58
TP53 P04637 1/20 0.58
PPARG P37231 1/20 0.58
NCOA2 Q15596 1/20 0.58
NCOA1 Q15788 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7217567 0.98 RAB9A (0.71) RAB9ANPC1SMN1; SMN2POLBCYP1A2
SCHEMBL11783793 0.98 RAB9A (0.71) RAB9ANPC1SMN1; SMN2POLBCYP1A2
SCHEMBL30582901 0.91 RAB9A (0.61) RAB9ANPC1SMN1; SMN2POLBCYP1A2
SCHEMBL30582902 0.89 RAB9A (0.63) RAB9ANPC1SMN1; SMN2POLBCYP1A2
SCHEMBL1713549 0.87 RAB9A (0.71) RAB9ANPC1SMN1; SMN2POLBCYP1A2
SCHEMBL3549560 0.87 RAB9A (0.61) RAB9ANPC1SMN1; SMN2POLBCYP1A2
SCHEMBL23965803 0.86 RAB9A (0.63) RAB9ANPC1SMN1; SMN2POLBCYP1A2
SCHEMBL3216411 0.86 RAB9A (0.60) RAB9ANPC1SMN1; SMN2POLBCYP1A2
SCHEMBL29561851 0.86 RAB9A (0.69) RAB9ANPC1SMN1; SMN2POLBCYP1A2
SCHEMBL9571707 0.86 RAB9A (0.69) RAB9ANPC1SMN1; SMN2POLBCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0230874-B1 BENZOTHIAZOLYLAZOLIDINES, AND THEIR PRODUCTION AND USE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1991-11-27 EP claimed
EP-0230874-A1 Benzothiazolylazolidines, and their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-08-05 EP claimed
CN-119855810-A General method for generating axial chirality through chiral accompaniment strategy and preparing axial chirality aromatic tertiary amine nitroxide ligand compound 中国科学院成都有机化学有限公司 2025-04-18 CN disclosed
CN-115850263-A 2, 7-disubstituted benzothiazole compound and application thereof 浙江工业大学 2023-03-28 CN disclosed
US-11161830-B2 4-pyridone compound or salt thereof, and pharmaceutical composition and formulation including same FUJIFILM CORPORATION (JP) 2021-11-02 US disclosed
US-11136317-B2 NADPH oxidase 4 inhibitors ACTELION PHARMACEUTICALS LTD (CH) 2021-10-05 US disclosed
US-20200165235-A1 NADPH OXIDASE 4 INHIBITORS ACTELION PHARMACEUTICALS LTD (CH) 2020-05-28 US disclosed
EP-2892892-A1 IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SNTHASE (FASN) INHIBITORS FOR!THE TREATMENT OF CANCER Janssen Pharmaceutica N.V. (BE) 2015-07-15 EP disclosed
WO-2014039769-A1 IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SNTHASE (FASN) INHIBITORS FOR|THE TREATMENT OF CANCER JANSSEN PHARMACEUTICA NV (BE) 2014-03-13 WO disclosed
WO-2011043942-A1 COMBINATION THERAPY USING A BETA 3 ADRENERGIC RECEPTOR AGONIST AND AN ANTIMUSCARINIC AGENT MERCK SHARP & DOHME CORP. (US) 2011-04-14 WO disclosed
EP-0927161-A1 SUBSTITUTED CYCLIC AMINE METALLOPROTEASE INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 1999-07-07 EP disclosed
US-4898948-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1990-02-06 US disclosed
US-4898948-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1990-02-06 US disclosed
US-4828605-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1989-05-09 US disclosed
US-4828605-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1989-05-09 US disclosed
EP-0311135-A2 Heterocyclic substituted azoles and azines, process for their preparation and their use as an agent with herbicide activity SCHERING AKTIENGESELLSCHAFT (DE) 1989-04-12 EP disclosed
US-4786310-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1988-11-22 US disclosed
US-4786310-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1988-11-22 US disclosed
EP-0230874-A1 Benzothiazolylazolidines, and their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-08-05 EP disclosed
EP-0230874-A1 Benzothiazolylazolidines, and their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-08-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11161830-B2 4-pyridone compound or salt thereof, and pharmaceutical composition and formulation including same HAVCR2, HBS1L, PHKB RAB9A 2878/4885NPC1 1739/4885SMN1; SMN2 4557/4885
US-20200165235-A1 NADPH OXIDASE 4 INHIBITORS NOX4, NOX1, CYBB RAB9A 2128/4885NPC1 3120/4885SMN1; SMN2 3582/4885
US-11136317-B2 NADPH oxidase 4 inhibitors NOX4, NOX1, CYBB RAB9A 2128/4885NPC1 3120/4885SMN1; SMN2 3582/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.