SCHEMBL7157673

SCHEMBL7157673

COc1cc(OC)c(NC(=S)Nc2ccc(NC(=O)c3sccc3Br)cc2)cc1Cl

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.54
CYP1A2 P05177 1/20 0.54
CYP3A4 P08684 1/20 0.54
CYP2D6 P10635 1/20 0.54
CYP2C9 P11712 1/20 0.54
CYP2C19 P33261 1/20 0.54
ALDH1A1 P00352 7/20 0.54
KMT2A Q03164 6/20 0.54
MEN1 O00255 5/20 0.54
LMNA P02545 4/20 0.54
HPGD P15428 2/20 0.54
KDM4E B2RXH2 2/20 0.50
HTT P42858 1/20 0.50
NPSR1 Q6W5P4 3/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
GAA P10253 1/20 0.47
F10 P00742 1/20 0.46
RECQL P46063 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6815346 0.81 MAPT (0.59) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL6815078 0.80 MAPT (0.62) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7939055 0.79 MAPT (0.70) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7165775 0.79 MAPT (0.67) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL6812142 0.79 MAPT (0.67) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL6811941 0.79 ALDH1A1 (0.74) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL6815648 0.78 MAPT (0.70) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7162969 0.78 MEN1 (0.78) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7164667 0.78 MEN1 (0.64) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7162179 0.78 KMT2A (0.54) MAPTCYP1A2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6555561-B2 N-(5-((((5-Chloro-2,4-dimethoxyphenyl)amino)thioxomethyl)-amino)-2 -pyridinyl)-2-methylbenzamide, for example; inhibiting replication of a herpes virus WYETH 2003-04-29 US disclosed