Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TPMT | P51580 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NEU3 | Q9UQ49 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL377395 | 0.83 | MAPK1 (0.53) | TSHRMAPK1TPMTTP53MEN1 | |
| SCHEMBL9318772 | 0.83 | TP53 (0.36) | TSHRMAPK1TP53NEU3HDAC8 | |
| SCHEMBL11292715 | 0.81 | LMNA (0.36) | TSHRMAPK1TPMTTP53NEU3 | |
| SCHEMBL9787545 | 0.81 | LMNA (0.36) | TSHRMAPK1TPMTTP53NEU3 | |
| Hydrochloric Acid SCHEMBL11407766 | 0.81 | MAPK1 (0.52) | TSHRMAPK1TPMTTP53MEN1 | |
| Hydrochloric Acid SCHEMBL9787540 | 0.79 | LMNA (0.35) | TPMTTP53NEU3HDAC8HDAC6 | |
| SCHEMBL28691627 | 0.78 | TSHR (0.50) | TSHRMAPK1TPMTMEN1KMT2A | |
| SCHEMBL9141564 | 0.77 | TSHR (0.58) | TSHRMAPK1TPMTMEN1CRHBP | |
| SCHEMBL9787542 | 0.76 | HDAC8 (0.37) | TSHRTP53HDAC8HDAC6HDAC2 | |
| SCHEMBL13628953 | 0.75 | TTR (0.44) | TSHRTP53HDAC8HDAC6HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6558665-B1 | Encapsulating particles with coatings that conform to size and shape of the particles | ARCH DEVELOPMENT CORPORATION | 2003-05-06 | — | — | US | disclosed |
| EP-0619716-B1 | CONTRAST MEDIA | NYCOMED IMAGING AS (NO) | 1998-08-05 | — | — | EP | disclosed |
| US-5733525-A | Method of EII using a water insoluble particulate agent | NYCOMED IMAGING AS (NO) | 1998-03-31 | — | — | US | disclosed |
| US-5651955-A | Method of electrical impedance imaging using ionic metal chelates | NYCOMED IMAGING AS (NO) | 1997-07-29 | — | — | US | disclosed |
| US-5639444-A | Method of electrical impedance imaging using a triiodophenyl compound or gas encapsulated microbubbles | NYCOMED IMAGING AS (NO) | 1997-06-17 | — | — | US | disclosed |
| EP-0619716-A1 | CONTRAST MEDIA | NYCOMED IMAGING AS (NO) | 1994-10-19 | — | — | EP | disclosed |
| WO-1993012717-A2 | CONTRAST MEDIA | COCKBAIN, JULIAN, RODERICK, MICHAELSON (GB) | 1993-07-08 | — | — | WO | disclosed |