Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 15/20 | 0.53 |
| ▸ | CA1 | P00915 | 13/20 | 0.53 |
| ▸ | CA12 | O43570 | 12/20 | 0.52 |
| ▸ | CA9 | Q16790 | 10/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | DBH | P09172 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 3/20 | 0.48 |
| ▸ | CA7 | P43166 | 3/20 | 0.48 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7911354 | 0.87 | CA2 (0.50) | CA2CA1CA12CA9CA6 | |
| SCHEMBL15045390 | 0.84 | ALDH1A1 (0.54) | KDM4EDBHGAARECQL | |
| SCHEMBL7913938 | 0.84 | CA2 (0.48) | CA2CA1CA12CA9CA6 | |
| SCHEMBL7917822 | 0.83 | CA2 (0.53) | CA2CA1CA12CA9CA6 | |
| SCHEMBL16473923 | 0.83 | GAA (0.44) | CA2CA1CA12CA9KDM4E | |
| SCHEMBL7914154 | 0.82 | CA2 (0.46) | CA2CA1CA12CA9CA6 | |
| SCHEMBL7911333 | 0.81 | CA2 (0.45) | CA2CA1CA12CA9CA6 | |
| SCHEMBL3347957 | 0.80 | CA2 (0.63) | CA2CA1CA12CA9CA6 | |
| SCHEMBL7914212 | 0.80 | CA2 (0.50) | CA2CA1CA12CA9CA6 | |
| SCHEMBL7911327 | 0.80 | CA2 (0.50) | CA2CA1CA12CA9CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1127479-C | Sulfonylurea derivatives and their use in the control of interleukin-1 activity | PFIZER (US) | 2003-11-12 | — | — | CN | disclosed |
| EP-0964849-B1 | SULFONYL UREA DERIVATIVES AND THEIR USE IN THE CONTROL OF INTERLEUKIN-1 ACTIVITY | PFIZER (US) | 2003-06-04 | — | — | EP | disclosed |
| EP-1270565-A1 | 4-Substituted furan-2-sulfonamide and its use in the preparation of sulfonyl urea derivatives | PFIZER INC. (US) | 2003-01-02 | — | — | EP | disclosed |
| EP-1270554-A1 | Sulfonyl urea derivatives and their use in the control of interleukin-1 activity | PFIZER INC. (US) | 2003-01-02 | — | — | EP | disclosed |
| US-6433009-B1 | TREATMENT OF AUTOIMMUNE, CARDIOVASCULAR, NERVOUS SYSTEM, GASTROINTESTINAL, RESPIRATORY SYSTEM, AND VIRAL DISORDERS; ANTIDIABETIC, ANTIARTHRITIC, ANTIINFLAMMATORY AND ANTIDEPRESSANT AGENTS | PFIZER INC | 2002-08-13 | — | — | US | disclosed |
| EP-1214087-A1 | COMBINATION TREATMENT WITH IL-1RA AND COMPOUNDS THAT INHIBIT IL-1 PROCESSING AND RELEASE | Pfizer Products Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019390-A1 | COMBINATION TREATMENT WITH IL-1RA AND DIARYL SULPHONYL UREA COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2001-03-22 | — | — | WO | disclosed |
| US-6166064-A | Sulfonyl urea derivatives and their use in the control of interleukin-1 activity | PFIZER INC (US) | 2000-12-26 | — | — | US | disclosed |
| CN-1245490-A | Sulfonyl urea derivatives and their use in control of interleukin-1 activity | PFIZER (US) | 2000-02-23 | — | — | CN | disclosed |
| CN-1021910-C | LANKACIDIN DERIVATIVES AND PRODUCTION THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1993-08-25 | — | — | CN | disclosed |