Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | MGAM | O43451 | 3/20 | 0.48 |
| ▸ | SI | P14410 | 3/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.48 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6058544 | 0.96 | GSTP1 (0.55) | GSTP1GAAMGAMSIMGAM2 | |
| SCHEMBL8435627 | 0.80 | NR4A2 (0.63) | GSTP1MEN1KMT2AMAOBMCL1 | |
| SCHEMBL6192316 | 0.76 | LMNA (0.63) | GSTP1GAALMNACYP1A2PTGS1 | |
| SCHEMBL2303383 | 0.75 | KDM1A (0.48) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL126452 | 0.74 | LMNA (0.70) | GSTP1GAALMNACYP1A2PTGS1 | |
| SCHEMBL22219371 | 0.73 | LMNA (0.59) | GSTP1GAAMGAMSIMGAM2 | |
| SCHEMBL28269246 | 0.73 | CTSV (0.48) | GSTP1GAALMNACYP1A2PTGS1 | |
| SCHEMBL3271153 | 0.72 | CYP4F2 (0.61) | GSTP1GAALMNACYP1A2PTGS1 | |
| SCHEMBL4910012 | 0.72 | MEN1 (0.62) | GSTP1GAALMNACYP1A2PTGS1 | |
| SCHEMBL6059000 | 0.72 | ESR1 (0.47) | GAAMGAMSIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6563008-B2 | Treatment of disorders linked to hypofolliculinemia and of certain estrogen-dependent pathologies such as prostatic adenomas or carcinomas, and of benign tumours of the breast | AVENTIS PHARMA S.A. (FR) | 2003-05-13 | — | — | US | disclosed |