Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 7/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | HSD17B14 | Q9BPX1 | 2/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28684912 | 0.86 | DHODH (0.39) | KEAP1HSD17B14NPC1RAB9A | |
| SCHEMBL30528245 | 0.84 | BCAT2 (0.55) | BCAT2PARP1CSNK1A1DYRK1BTYRO3 | |
| SCHEMBL30528244 | 0.84 | BCAT2 (0.55) | BCAT2PARP1CSNK1A1DYRK1BTYRO3 | |
| SCHEMBL696661 | 0.84 | BCAT2 (0.55) | BCAT2PARP1CSNK1A1DYRK1BTYRO3 | |
| SCHEMBL3423724 | 0.83 | BCAT2 (0.42) | BCAT2PARP1CSNK1A1DYRK1BTYRO3 | |
| SCHEMBL7159631 | 0.82 | BCAT2 (0.41) | BCAT2PARP1CSNK1A1DYRK1BTYRO3 | |
| SCHEMBL3418979 | 0.82 | BCAT2 (0.41) | BCAT2PARP1CSNK1A1DYRK1BTYRO3 | |
| SCHEMBL5117078 | 0.81 | BCAT2 (0.51) | BCAT2PARP1CSNK1A1DYRK1BTYRO3 | |
| SCHEMBL29543435 | 0.81 | PARP1 (0.41) | BCAT2PARP1CSNK1A1DYRK1BTYRO3 | |
| SCHEMBL3421536 | 0.79 | BCAT2 (0.39) | BCAT2PARP1CSNK1A1DYRK1BTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320531-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002012242-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2002-02-14 | — | — | WO | disclosed |