Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Trientine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.65 |
| ▸ | CA6 | P23280 | 5/20 | 0.65 |
| ▸ | CA7 | P43166 | 5/20 | 0.65 |
| ▸ | CA9 | Q16790 | 5/20 | 0.65 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.65 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | CA2 | P00918 | 4/20 | 0.65 |
| ▸ | CA4 | P22748 | 4/20 | 0.65 |
| ▸ | CA5A | P35218 | 4/20 | 0.65 |
| ▸ | CA3 | P07451 | 3/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | CA1 | P00915 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | RECQL | P46063 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL8393633 | 0.97 | CA12 (0.62) | CA12CA6CA7CA9CA14 | |
| Sulfuric Acid SCHEMBL29104260 | 0.94 | CA12 (0.59) | CA12CA6CA7CA9CA14 | |
| Sulfuric Acid SCHEMBL28250202 | 0.94 | CA12 (0.59) | CA12CA6CA7CA9CA14 | |
| Sulfuric Acid SCHEMBL11334847 | 0.94 | CA12 (0.59) | CA12CA6CA7CA9CA14 | |
| Trientine SCHEMBL11114075 | 0.92 | CA6 (0.61) | CA12CA6CA7CA9CA14 | |
| Sulfamate SCHEMBL18544319 | 0.92 | CA6 (0.61) | CA12CA6CA7CA9CA14 | |
| Sulfamate SCHEMBL18544358 | 0.88 | CA9 (0.59) | CA12CA6CA7CA9CA14 | |
| Sulfuric Acid SCHEMBL29044697 | 0.88 | CA12 (0.50) | CA12CA6CA7CA9CA14 | |
| Sulfuric Acid SCHEMBL17673120 | 0.87 | CA12 (0.50) | CA12CA6CA7CA9CA14 | |
| Sulfuric Acid SCHEMBL701165 | 0.87 | CA12 (0.50) | CA12CA6CA7CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293673-B2 | Process for preparing 4-aminodiphenylamine | JIANGSU SINORGCHEM TECHNOLOGY CO., LTD. (CN) | 2012-10-23 | — | — | US | claimed |
| EP-1645555-B1 | A METHOD FOR PRODUCING 4-AMINODIPHENYLAMINE | JIANGSU SINORGCHEM TECH CO LTD (CN) | 2011-09-28 | — | — | EP | claimed |
| EP-1591438-B1 | A PROCESS FOR PREPARING 4-AMINODIPHENYLAMINE | SINORGCHEM CO SHANDONG (CN) | 2007-11-21 | — | — | EP | claimed |
| US-20070232832-A1 | PROCESS FOR PREPARING 4-AMINODIPHENYLAMINE | SINORGCHEM CO. | 2007-10-04 | — | — | US | claimed |
| US-7235694-B2 | Reacting nitrobenzene and aniline in presence of a powdery complex base catalyst to perform condensation, hydrogenation, separation and refining; reuse the catalyst; tetraalkyl ammonium hydroxide and a tetraalkyl ammonium salt | SINORGCHEM CO., SHANDONG (CN) | 2007-06-26 | — | — | US | claimed |
| US-7176333-B2 | Process for preparing 4-aminodiphenylamine | SINORGCHEM COMPANY, SHANDONG (CN) | 2007-02-13 | — | — | US | claimed |
| US-7084302-B2 | reacting nitrobenzene and aniline in presence of condensation basic catalyst to form mixtures of 4-nitrodiphenylamine and 4-nitrosodiphenylamine, then reacting with hydrogen in the presence of hydrogenation catalysts, separation and refining | SINORGCHEM SHANDONG CO., LTD. (CN) | 2006-08-01 | — | — | US | claimed |
| EP-1645555-A1 | A METHOD FOR PRODUCING 4-AMINODIPHENYLAMINE | Shi, Guangqiang (CN) | 2006-04-12 | — | — | EP | claimed |
| EP-1591438-A1 | A PROCESS FOR PREPARING 4-AMINODIPHENYLAMINE | Wang, Nongyue (CN) | 2005-11-02 | — | — | EP | claimed |
| US-20050240058-A1 | reacting nitrobenzene and aniline in presence of condensation basic catalyst to form mixtures of 4-nitrodiphenylamine and 4-nitrosodiphenylamine, then reacting with hydrogen in the presence of hydrogenation catalysts, separation and refining | NONGYUE WANG AND GUANGQIANG SHI (CN) | 2005-10-27 | — | — | US | claimed |
| US-20050065376-A1 | Process for preparing 4-aminodiphenylamine | GUANGQIANG SHI AND NONGYUE WANG (CN) | 2005-03-24 | — | — | US | claimed |
| CN-116904746-A | Recycling treatment method of zinc-containing raw material | 北京中金瑞丰环保科技有限公司 | 2023-10-20 | — | — | CN | disclosed |
| US-9029603-B2 | Process for preparing alkylated p-phenylenediamines | JIANGSU SINORGCHEM TECHNOLOGY CO., LTD. (CN) | 2015-05-12 | — | — | US | disclosed |
| US-20130066113-A1 | PROCESS FOR PREPARING ALKYLATED P-PHENYLENEDIAMINES | JIANGSU SINORGCHEM TECHNOLOGY CO., LTD. (CN) | 2013-03-14 | — | — | US | disclosed |
| US-8293673-B2 | Process for preparing 4-aminodiphenylamine | JIANGSU SINORGCHEM TECHNOLOGY CO., LTD. (CN) | 2012-10-23 | — | — | US | disclosed |
| US-7084302-B2 | reacting nitrobenzene and aniline in presence of condensation basic catalyst to form mixtures of 4-nitrodiphenylamine and 4-nitrosodiphenylamine, then reacting with hydrogen in the presence of hydrogenation catalysts, separation and refining | SINORGCHEM SHANDONG CO., LTD. (CN) | 2006-08-01 | — | — | US | disclosed |
| EP-1645555-A1 | A METHOD FOR PRODUCING 4-AMINODIPHENYLAMINE | Shi, Guangqiang (CN) | 2006-04-12 | — | — | EP | disclosed |
| EP-1591438-A1 | A PROCESS FOR PREPARING 4-AMINODIPHENYLAMINE | Wang, Nongyue (CN) | 2005-11-02 | — | — | EP | disclosed |
| US-20050240058-A1 | reacting nitrobenzene and aniline in presence of condensation basic catalyst to form mixtures of 4-nitrodiphenylamine and 4-nitrosodiphenylamine, then reacting with hydrogen in the presence of hydrogenation catalysts, separation and refining | NONGYUE WANG AND GUANGQIANG SHI (CN) | 2005-10-27 | — | — | US | disclosed |
| US-20050065376-A1 | Process for preparing 4-aminodiphenylamine | GUANGQIANG SHI AND NONGYUE WANG (CN) | 2005-03-24 | — | — | US | disclosed |