Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.46 |
| ▸ | PYGL | P06737 | 13/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.43 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.43 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PYGM | P11217 | 4/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7164337 | 0.81 | MAP2K1 (0.46) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL6952084 | 0.77 | MAP2K1 (0.47) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL5384280 | 0.75 | KMT2A (0.47) | MAP2K1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL5396229 | 0.75 | MAP2K1 (0.77) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL6944261 | 0.72 | MAP2K1 (0.49) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL5382341 | 0.71 | MAP2K1 (0.60) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL5396163 | 0.71 | MAP2K1 (0.62) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL6950685 | 0.70 | MAP2K1 (0.54) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL6948491 | 0.70 | MAP2K1 (0.47) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 | |
| SCHEMBL7853481 | 0.70 | MAP2K1 (0.44) | MAP2K1RAF1PDGFRBCSNK2A2MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506798-B1 | 4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors | WARNER-LAMBERT COMPANY | 2003-01-14 | — | — | US | disclosed |