Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.54 |
| ▸ | TNF | P01375 | 1/20 | 0.54 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | ALPL | P05186 | 2/20 | 0.51 |
| ▸ | ALPG | P10696 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ALPI | P09923 | 1/20 | 0.51 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2882482 | 0.84 | TDP1 (0.59) | TDP1KDM4ENPC1CYP11B1CYP11B2 | |
| SCHEMBL7732690 | 0.84 | TDP1 (0.59) | TDP1KDM4ENPC1CYP11B1CYP11B2 | |
| SCHEMBL26818584 | 0.84 | KDM4E (0.60) | TDP1KDM4ENPC1CYP11B1CYP11B2 | |
| SCHEMBL8017568 | 0.81 | TDP1 (0.56) | TDP1KDM4ENPC1CYP11B1CYP11B2 | |
| SCHEMBL11498670 | 0.80 | KDM4E (0.56) | TDP1KDM4ENPC1CYP11B1CYP11B2 | |
| SCHEMBL27864830 | 0.80 | TDP1 (0.63) | TDP1KDM4ENPC1CYP11B1CYP11B2 | |
| SCHEMBL1035783 | 0.79 | EGLN3 (0.71) | TDP1KDM4ENPC1CYP11B1CYP11B2 | |
| SCHEMBL1038315 | 0.77 | KDM4E (0.69) | TDP1KDM4ENPC1CYP11B1CYP11B2 | |
| SCHEMBL11460254 | 0.77 | KDM4E (0.65) | TDP1KDM4ENPC1CYP11B1CYP11B2 | |
| SCHEMBL10881570 | 0.77 | KDM4E (0.65) | TDP1KDM4ENPC1EGLN3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828487-B1 | AGENTS FOR USE AGAINST PARASITIC PROTOZOA | BAYER AG (DE) | 2003-11-26 | — | — | EP | disclosed |
| EP-0828487-A1 | AGENTS FOR USE AGAINST PARASITIC PROTOZOA | BAYER AG (DE) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038140-A1 | AGENTS FOR USE AGAINST PARASITIC PROTOZOA | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-05 | — | — | WO | disclosed |
| US-4649042-A | SUSTAINED RELEASE, DRUGS, GLYCOLIC ACID-LACTIC ACID COPOLYMER CORE, TUBES, ELASTICITY, SEALS | ELI LILLY AND COMPANY (US) | 1987-03-10 | — | — | US | disclosed |
| EP-0211489-A2 | Derivatives of 2-fluoroalkylbenzimidazole, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1987-02-25 | — | — | EP | disclosed |
| EP-0164241-A2 | Improvements in or relating to a rumen delivery device | ELI LILLY AND COMPANY (US) | 1985-12-11 | — | — | EP | disclosed |