Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 8/20 | 0.54 |
| ▸ | NOS2 | P35228 | 5/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.51 |
| ▸ | NOS3 | P29474 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5338014 | 0.86 | NOS1 (0.59) | NOS1NOS2HRH3NOS3KCNH2 | |
| SCHEMBL25380997 | 0.76 | KCNH2 (0.75) | NOS1NOS2NOS3KCNH2 | |
| SCHEMBL13886624 | 0.73 | TAAR1 (0.66) | HRH3ALOX5FFAR1 | |
| SCHEMBL3928241 | 0.71 | MAOB (0.53) | KCNH2 | |
| SCHEMBL3052357 | 0.69 | HRH3 (0.72) | HRH3KCNH2KEAP1NFE2L2 | |
| SCHEMBL928390 | 0.68 | HRH3 (0.77) | HRH3KCNH2KEAP1NFE2L2 | |
| SCHEMBL10662153 | 0.67 | HRH3 (0.77) | HRH3KCNH2KEAP1NFE2L2 | |
| SCHEMBL19685842 | 0.67 | KCNH2 (0.59) | KCNH2ALOX5 | |
| SCHEMBL11065856 | 0.67 | NOS2 (0.45) | NOS1NOS2NOS3 | |
| SCHEMBL3928236 | 0.67 | BACE1 (0.45) | NOS1NOS2NOS3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309589-A2 | UREA COMPOUNDS AND METHODS OF USES | Amgen Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | disclosed |