Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7807694 | 0.99 | MCL1 (0.46) | MCL1GAABCL2A1GFERAPOBEC3G | |
| Hydrochloric Acid SCHEMBL5469099 | 0.87 | HPGD (0.39) | ALDH1A1LMNASMN1; SMN2HPGDTSHR | |
| SCHEMBL6572695 | 0.86 | HPGD (0.39) | ALDH1A1LMNASMN1; SMN2HPGDTSHR | |
| Hydrochloric Acid SCHEMBL7161837 | 0.85 | KMT2A (0.42) | GAAGFERAPOBEC3GERBB2HSP90AA1 | |
| Hydrochloric Acid SCHEMBL6939292 | 0.84 | HPGD (0.43) | GAAALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL7806178 | 0.84 | KMT2A (0.43) | GAAGFERAPOBEC3GERBB2HSP90AA1 | |
| Hydrochloric Acid SCHEMBL7156607 | 0.83 | KMT2A (0.43) | GAAGFERAPOBEC3GERBB2MAPT | |
| SCHEMBL6946140 | 0.83 | HPGD (0.44) | GAAMAPTALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL7160339 | 0.82 | G6PD (0.40) | GAAGFERAPOBEC3GMAPTALDH1A1 | |
| SCHEMBL7804320 | 0.82 | KMT2A (0.44) | GAAGFERAPOBEC3GERBB2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | claimed |
| US-6537329-B1 | Intense colorations with a wide range of colours, excellent colorfastness | L'OREAL S.A. (FR) | 2003-03-25 | — | — | US | disclosed |