SCHEMBL7160791

SCHEMBL7160791

C#CCN.COC(=O)c1cc(Br)c(-c2ccc(O[Si](C)(C)C(C)(C)C)cc2)c(C#CCN(C)C)c1

nearest known ligand 0.36

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HTR1D P28221 1/20 0.36
HTR1B P28222 1/20 0.36
PREP P48147 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6697474 0.94 HTR1D (0.39) HTR1DHTR1BPREP
SCHEMBL6058554 0.92 PREP (0.34) HTR1DHTR1BPREP
SCHEMBL6705270 0.74 PREP (0.44) PREP
Biphenyl SCHEMBL7167410 0.70 PREP (0.40) PREP
SCHEMBL6701789 0.65 HPGD (0.47) PREP
SCHEMBL8906116 0.65 CA1 (0.56) PREP
SCHEMBL20487829 0.64 KDM4E (0.39) PREP
SCHEMBL6058804 0.63 PREP (0.46) PREP
SCHEMBL18304558 0.62 KDM4E (0.44)
SCHEMBL6625609 0.62 KDM4E (0.44) PREP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6563008-B2 Treatment of disorders linked to hypofolliculinemia and of certain estrogen-dependent pathologies such as prostatic adenomas or carcinomas, and of benign tumours of the breast AVENTIS PHARMA S.A. (FR) 2003-05-13 US disclosed