Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.30 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9990991 | 0.98 | NLRP3 (0.42) | NLRP3TSHRCYP3A4ALDH1A1TDP1 | |
| SCHEMBL1445271 | 0.90 | — | — | |
| SCHEMBL3986656 | 0.79 | — | — | |
| SCHEMBL5880394 | 0.79 | FAAH (0.35) | — | |
| SCHEMBL18110382 | 0.79 | FAAH (0.35) | — | |
| SCHEMBL4107225 | 0.79 | FAAH (0.35) | — | |
| SCHEMBL5903659 | 0.79 | FAAH (0.35) | — | |
| SCHEMBL3107944 | 0.77 | NLRP3 (0.46) | NLRP3TSHRCYP3A4ALDH1A1TDP1 | |
| SCHEMBL21616867 | 0.76 | NLRP3 (0.65) | NLRP3TSHRALDH1A1TDP1MAPT | |
| SCHEMBL21616866 | 0.76 | NLRP3 (0.65) | NLRP3TSHRALDH1A1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789578-B1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2003-06-04 | — | — | EP | disclosed |
| EP-0789578-A4 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2000-09-20 | — | — | EP | disclosed |
| US-5990083-A | Multicatalytic protease inhibitors | CEPHALON, INC. (US) | 1999-11-23 | — | — | US | disclosed |
| US-5830870-A | PREVENT LOSS OF MUSCLE MASS | CEPHALON, INC. (US) | 1998-11-03 | — | — | US | disclosed |
| CN-1164192-A | Inhibitors of heterogeneously catalyzed proteases | CEPHALON INC (US) | 1997-11-05 | — | — | CN | disclosed |
| EP-0789578-A1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1997-08-20 | — | — | EP | disclosed |
| US-5614649-A | TREATMENT OF MUSCULAR DISORDERS, SUBSTITUTED GUANIDINES | CEPHALON, INC. (US) | 1997-03-25 | — | — | US | disclosed |
| US-5550262-A | TREATMENT OF MUSCLES WASTING DISEASES | CEPHALON, INC. (US) | 1996-08-27 | — | — | US | disclosed |
| WO-1996014857-A1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1996-05-23 | — | — | WO | disclosed |