SCHEMBL716262

SCHEMBL716262

Cc1nc(N)nc(NC(C)c2cc3cccc(Cl)c3nc2N2CCC(F)(F)C2)n1

nearest known ligand 0.37

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 3/20 0.37
CNR2 P34972 15/20 0.37
PIK3R2 O00459 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
CNR1 P21554 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15875822 1.00 PIK3CD (0.37) PIK3CDCNR2PIK3R2MEN1KMT2A
SCHEMBL15875851 0.88 PIK3CD (0.41) PIK3CDCNR2CNR1
SCHEMBL716959 0.84 PIK3CB (0.39) PIK3CDPIK3R2
SCHEMBL716761 0.84 PIK3CD (0.37) PIK3CDPIK3R2MEN1KMT2A
SCHEMBL715637 0.84 PIK3CD (0.37) PIK3CDPIK3R2MEN1KMT2A
SCHEMBL716382 0.83 PIK3CD (0.37) PIK3CDCNR2PIK3R2
SCHEMBL716716 0.83 PIK3CD (0.37) PIK3CDCNR2PIK3R2
SCHEMBL15875858 0.83 PIK3CD (0.38) PIK3CDCNR2PIK3R2MEN1KMT2A
SCHEMBL15875804 0.81 PIK3CA (0.39) PIK3CDCNR2PIK3R2MEN1KMT2A
SCHEMBL15875870 0.81 PIK3CB (0.39) PIK3CDPIK3R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2403847-B1 TRIAZINE DERIVATIVES AS KINASE INHIBITORS UCB BIOPHARMA SPRL (BE) 2016-03-02 EP claimed
EP-2403847-B1 TRIAZINE DERIVATIVES AS KINASE INHIBITORS UCB BIOPHARMA SPRL (BE) 2016-03-02 EP disclosed
US-20120053167-A1 Triazine Derivatives as Kinase Inhibitors UCB PHARMA, S.A. (BE) 2012-03-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120053167-A1 Triazine Derivatives as Kinase Inhibitors MAP3K15, PI4KA, MAP3K20 PIK3CD 12/4885CNR2 1488/4885PIK3R2 93/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.