Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7162842 | 0.86 | HSD17B10 (0.40) | CYP1A2CYP2C9CYP2C19NPC1MAPT | |
| SCHEMBL7160132 | 0.84 | KDM4E (0.40) | BRD4BRD2CREBBPNPC1MAPT | |
| SCHEMBL7160156 | 0.83 | CA12 (0.38) | NPC1RAB9AALDH1A1SMN1; SMN2HTR2C | |
| SCHEMBL7160366 | 0.81 | PLK1 (0.45) | BRD4BRD2CREBBPALDH1A1POLB | |
| SCHEMBL7160050 | 0.79 | MAPT (0.43) | CYP1A2CYP2C9CYP2C19NPC1MAPT | |
| SCHEMBL2779491 | 0.77 | CYP1A2 (0.41) | CYP1A2CYP2C9CYP2C19NPC1MAPT | |
| SCHEMBL22890728 | 0.76 | ALDH1A1 (0.41) | CYP1A2CYP2C9CYP2C19BRD4NPC1 | |
| SCHEMBL7162867 | 0.74 | GRIA1 (0.56) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| SCHEMBL7162885 | 0.74 | GRIA1 (0.56) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| SCHEMBL7162826 | 0.73 | MAPK1 (0.35) | CYP1A2CYP2C19MAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934286-B1 | 3-ALKOXYISOXAZOL-4-YL-SUBSTITUTED 2-AMINO CARBOXYLIC ACID COMPOUNDS | LUNDBECK & CO AS H (DK) | 2003-01-08 | — | — | EP | disclosed |
| US-6200999-B1 | ALZHEIMER*S, HUNTINGTON*S, AND PARKINSON*S DISEASE; ANTIEPILEPTIC, ANALGESIC, ANXIOLYTIC, ANTIISCHEMIC AND ANTIDEPRESSANT AGENTS; NMDA AND AMPA RECEPTOR LIGANDS | H. LUNDBECK A/S (DK) | 2001-03-13 | — | — | US | disclosed |
| EP-0934286-A1 | 3-ALKOXYISOXAZOL-4-YL-SUBSTITUTED 2-AMINO CARBOXYLIC ACID COMPOUNDS | H. LUNDBECK A/S (DK) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998015542-A1 | 3-ALKOXYISOXAZOL-4-YL-SUBSTITUTED 2-AMINO CARBOXYLIC ACID COMPOUNDS | H. LUNDBECK A/S (DK) | 1998-04-16 | — | — | WO | disclosed |